Yoruba medicinal formulations derived from plant extracts are fast becoming one of the most widely consumed medicinal formulation in the rural areas of Nigeria. The aim of this study was to screen evaluate the effect of this medicinal formulation on cetain biochemical parameters of wistar albino rats. Sixty-four rats irrespective of sex were used in this study. They were divided into six groups (control and Groups A-E); with groups A-E split into three groups for testing at week 2, 4 and 6. Each sub group contained four rats and was administered 2.9μl/Kg B.W of each medicinal formulation. Cage side examination was done daily to observe overt signs of toxicity (salivation, lacrimation, yellowing of fur etc). The formulation resulted in a significant increase then reduction in the body weight. Markers of hepatocyte injury; alanine transaminase and aspartate transaminase, were initially reduced but increased at week 4. Same was observed for the cholestasis marker alkaline phosphatase. The levels of serum creatinine, urea and blood urea nitrogen steadily reduced over time. The histological findings of the liver sections indicated gross cirrhosis, degeneration, inflammation and apoptosis in the experimented groups as compared to the control group.
Keywords
Yoruba, Biochemical Parameters
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