Indian Journal of Forensic Medicine & Toxicology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Study of Protective effect of Ginger (Zingiber Officinale) in Normal and Carbon-Tetrachloride Induced Hepatotoxic Rats in Western U.P. India


Affiliations
1 Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, U.P., India
2 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., India
3 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., India
     

   Subscribe/Renew Journal


The current study has been conducted to investigate the affect of ginger on hepatic antioxidant enzymes system in carbon tetrachloride induced hepatotoxic rats. The first set of animals received only ginger-supplemented diet while the another set were treated with CCl4 before maintaining them on ginger-based diets.Consumption of the experimental diets by the normal rats produced significant elevation (p<0.05) in the activities of the hepatic aspartate aminotransferase and alanine aminotransferase as well as the concentration of protein and albumin. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters . However, the significantly reduced (p<0.05) marker enzymes such as AST, ALT, due to CCl4 treatment were restored towards normalization on consumption of ginger diet. The biochemical parameters like total protein and albumin were also restored towards normal levels. The findings indicate that the ginger is an efficient hepatoprotective and antioxidant agent against CCl4-induced liver toxicity.

Keywords

Aminotransferases, Carbon tetrachloride (CCl4), De novo synthesis Hepatotoxicity, Spices
Subscription Login to verify subscription
User
Notifications
Font Size


  • KM Nadkarni; AK Nadkarni. In: Indian Materia Medica, 3rd Ed., Popular Prakashan Ltd.,Bombay. 1976

  • K Srinivasan. Food Rev.Int. 2005 , 21, 167-188.

  • E Langner; S Greifenberg; J Gruenwald. Adv Ther, 1998, 15, 25.

  • S Arctangder. In Perfume and Flavour Materials of Natural Origin, Elizabeth Publisher, USA, 1960, pp. 275.

  • HK Bakhru. In Herbs That Heal: Natural Remedies for Good Health. Oriental Paper Backs, New Delhi, 1999, pp. 97.

  • SA Meyer; AP Kulkarni. In: Introduction to biochemical toxicology. 3rd Ed., John Wiley and Sons, New-York, 2001, pp. 487.

  • PL Wolf. Ind. J. Clin. Biochem. 1999, 14, 59-64.

  • M Guntupalli; V Chandana; P Pushpangadan; I Annie Shirwaikar. J. Ethnopharmacol. 2006,103, 484–490

  • SB Rao; HM Mehendale. Biochem. J. 1989, 262, 721-725

  • EO Ngaha. Biochem. Pharmacol., 1982, 3,1843- 1847.

  • E Malloy; K Evelyn. J. Biol. Chem. 1937, 119, 481- 485.

  • DT Plummer. In An introduction to Practical Biochemistry. 2nd Ed. McGraw- Hill,London, 1978, pp. 144-145

  • S Reitman; S Frankel. Am. J. Clin. Pathol., 1957, 28, 56-63

  • RF Woodson. (1983). In Probability and Mathematical Statistics. Wiley, Chichester, 1983, pp. 315-316.

  • O. Ulican; M Greksak; O Vancova; L Zlatos; S Galbavy; P Bozek; M Nakano. Physiol. Res. 2003, 52, 461-466.

  • E Porchezhian; SHAnsari. Phytomed. 2005, 12, 62-64.

  • H Wada; EE Snell. J. Biol. Chem. 1962, 237, 133-137.

  • RM Wells; RH Mclntyre; AK Morgan; PS Davies. Comp. Biochem. Physiol. 1986, 64A, 565-571.

  • MT Yakubu; MA Akanji; IO Salau. Nig. J. Biochem. Mol. Biol., 2001, 16(2): 177-182.

  • AK Mujumddar; AS Upadhye; AM Pradhan. Ind. J. Pharm. Sci. 1998, 60, 363.

  • AR Opoku; IM Ndlovu; SE Terblanche; AH Hutchings. South Afr. J. Bot. 2007, 73, 372–377.

  • Y Aniya; T Koyama; C Miyagi; M Miyahira; C Inomata; S Kinoshita; T Ichiba. Biol. Pharm. Bull. 2005, 28, 19-23.


Abstract Views: 477

PDF Views: 0




  • A Study of Protective effect of Ginger (Zingiber Officinale) in Normal and Carbon-Tetrachloride Induced Hepatotoxic Rats in Western U.P. India

Abstract Views: 477  |  PDF Views: 0

Authors

Harsh Misra
Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, U.P., India
Hemant Kumar Sharma
Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, U.P., India
Beena Shukla
Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., India
Yogesh Kumar Rai
Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., India

Abstract


The current study has been conducted to investigate the affect of ginger on hepatic antioxidant enzymes system in carbon tetrachloride induced hepatotoxic rats. The first set of animals received only ginger-supplemented diet while the another set were treated with CCl4 before maintaining them on ginger-based diets.Consumption of the experimental diets by the normal rats produced significant elevation (p<0.05) in the activities of the hepatic aspartate aminotransferase and alanine aminotransferase as well as the concentration of protein and albumin. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters . However, the significantly reduced (p<0.05) marker enzymes such as AST, ALT, due to CCl4 treatment were restored towards normalization on consumption of ginger diet. The biochemical parameters like total protein and albumin were also restored towards normal levels. The findings indicate that the ginger is an efficient hepatoprotective and antioxidant agent against CCl4-induced liver toxicity.

Keywords


Aminotransferases, Carbon tetrachloride (CCl4), De novo synthesis Hepatotoxicity, Spices

References