Indian Journal of Forensic Medicine & Toxicology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Study of Disseminated Intravascular Coagulation in Routine Autopsies


Affiliations
1 Dept. of Forensic Medicine, Sri Siddhartha Medical College, Tumkur, Karnataka, India
     

   Subscribe/Renew Journal


The present study was on Incidence of Disseminated Intravascular Coagulation(DIC) in routine autopsies. In this Four year period (Jan 2003 to Dec 2006) of study, a total of 418 Medico legal autopsies were conducted of which 21 cases proved DIC. The study has been ventured primarily based on morbid anatomical and histo-pathological findings. Wherever possible clinical orientation has been attempted perusing antecedent case history and case records as and when available. The presence of single Microthrombi in minimum of one of the organs was considered to be DIC. The study also pointed out the discrepancies between clinical diagnosis and autopsy findings and also pointed out the clinical lapses in its diagnosis. The study also highlighted the incidental findings of DIC in Burns and Trauma cases, & also highlited the need for the alertness of Clinicians in cases suspected to manifest into DIC. Of the total number of DIC(n=21) cases only 12 were treated in the Hospital out of which only 2 cases were suspected for DIC. The majority of Microthrombi was in Kidney(71.43%) and Lungs(66.66%). and the least was spleen(n=1). The maximum haemorrhage were reported in Kidney(n=11) and the least was in the Liver and Brain. The external manifestation of Haemorrhage was only in few (n=3) cases. The study also highlighted the importance of DIC as Immediate Cause of death due to various underlying mechanisms.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Albrecht H, Skorde J, Arasteh K, Heise W, Stellbrink HJ, Grosse G, L’Age M. Disseminated Intravascular Coagulation in AIDS patients-report of 16 cases, Scand J Infect Dis.1995; 27(1):71-4.

  • Bhatia S. Ranadive N, Manek R, Deodhar K. India J Pathol Microbiol. 1998, Jan; 41(1):71-6.

  • Burton P. Drayer, M.D. Charles M. Poser MD, Disseminated Intravascular Coagulation and Head Trauma, JAMA, 231; 174-175, 1975.

  • Davies-Jones GAB, Preston FE, Timperely WR. Neurological complication in clinical haematology. Oxford: Blackwell Scientific, 1980:193

  • Goldman I. Diagnostic advances V the value of the autopsy. Arch Pathol Lab Med, 1984;108:501-5.

  • Grodwalls Forensic Pathology, Ch 4;2nd edi,1976:pp57. 7. Hill R.B., Anderson R.E. The recent history of the autopsy. Arch Pathol Med 1996;120:702-12.

  • Kaufman HH, Hui K-S, Mattson JC, et al. Clinicopathological correlation of DIC. in patients with Head injury. Neurosurgery 1984;15:34-42.

  • Kavatkar AN, Sahasrabudhe NS, Jadhav MV, Deshmukh SD. Int J Gynaecol Obstet. 2003 April; 81(1):1-8

  • Kim HS, Suzuki M, Lie JT, Titus JL: Clinically unsuspected Disseminated Intravascular Coagulation. An autopsy survey. Am J Clin Pathol 66:31,1976.

  • Kojima M, Shimamura K, Mori N, Oka K, Nakazawa M.A histological study on microthrombi in autopsy cases of DIC. Bibl Haematol 1983; 49:95-106.

  • Liu L, Wang Z, Zhang X, Bu H,Qin Z. Pleural malignant mesothelioma complicated with Disseminated Intravascular Coagulation, Hua xi yi ke da Xue Xue Bao, 1993 Dec; 24(4):426-8.

  • McKay DG. Progress in Disseminated Intravascular Coagulation. Calif Med 1969; 111:186-99

  • Minna JD, Robboy SJ, Colman RW: Disseminated Intravascular Coagulation in man. Charles C. Thomas, Springfield, IL.1974.

  • Milani Junior R, Jorge MT, de Campos FP, Martins FP, et al, Snake bites by the jaracucu: Clinicopathological studies of 29 proven cases in Sao Paulo State, Brazil.

  • Robbins Pathologic basis of Diseases, Disseminated Intravascular Coagulation. 4th edi, 1989, pp698-99.

  • Stainley. J. Robby, Major MC, Colman RW, Minna JD., Pathology of Disseminated Intravascular Coagulation. Analysis of 26 cases, Hum Pathol. 1971 Sep:3(3):327-43.

  • Tovi D: Fibrinolytic activity of human brain: A histochemical study, Acta Neurol Scand 49:152-162,1973.

  • Takashima S, Koga N, Tanaka Ki Fibrinolytic activity of human brain and Cerbrospinal Fluid, 80.J.Exp Pathol 50:533-539; 1969.

  • Williams Haematology, Disseminated Intravascular Coagulation, 1986., 126,1677-82.

  • Wilde JT, Roberts KM, Greaves M, Preston FE:Association between necropsy evidence of Disseminated Intravascular Coagulation and coagulation variables before death in patients in intensive care units. J Clin Pathol 41:138,1988.


Abstract Views: 671

PDF Views: 2




  • A Study of Disseminated Intravascular Coagulation in Routine Autopsies

Abstract Views: 671  |  PDF Views: 2

Authors

Dinesh Rao
Dept. of Forensic Medicine, Sri Siddhartha Medical College, Tumkur, Karnataka, India

Abstract


The present study was on Incidence of Disseminated Intravascular Coagulation(DIC) in routine autopsies. In this Four year period (Jan 2003 to Dec 2006) of study, a total of 418 Medico legal autopsies were conducted of which 21 cases proved DIC. The study has been ventured primarily based on morbid anatomical and histo-pathological findings. Wherever possible clinical orientation has been attempted perusing antecedent case history and case records as and when available. The presence of single Microthrombi in minimum of one of the organs was considered to be DIC. The study also pointed out the discrepancies between clinical diagnosis and autopsy findings and also pointed out the clinical lapses in its diagnosis. The study also highlighted the incidental findings of DIC in Burns and Trauma cases, & also highlited the need for the alertness of Clinicians in cases suspected to manifest into DIC. Of the total number of DIC(n=21) cases only 12 were treated in the Hospital out of which only 2 cases were suspected for DIC. The majority of Microthrombi was in Kidney(71.43%) and Lungs(66.66%). and the least was spleen(n=1). The maximum haemorrhage were reported in Kidney(n=11) and the least was in the Liver and Brain. The external manifestation of Haemorrhage was only in few (n=3) cases. The study also highlighted the importance of DIC as Immediate Cause of death due to various underlying mechanisms.

References