Indian Journal of Geo-Marine Sciences

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Cardio Protective Activity of Sargassum wightii on Isoproterenol Induced Myocardial Stress in Rats


Affiliations
1 Department of Food Processing Technology, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, Tamil Nadu – 641 114, India
2 Department of Biotechnology, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, Tamil Nadu – 641 114, India
3 Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu – 600 119, India
4 School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP2, Bandar Saujana Putra, 42610, Jenjarom, Selangor, Malaysia
5 Department of Microbiology, Sree Narayana College, Alathur, Palakkad, Kerala – 678 682, India
6 Department of Microbiology, Kamaraj College, Thoothukudi, Thirunelveli, Tamil Nadu – 628 003, India
 

The aim of this investigation is to determine whether the methanolic extracts of Sargassum wightii can protect rats against isoproterenol-induced myocardial infarction. Four different groups of rats (6 rats in each group) were taken; where group 1 comprised of normal untreated rats, group 2 was injected with Isoproterenol (synthetic catecholamine), group 3 was considered as standard and hence, was injected with Isoproterenol + Simvastatin and group 4 was treated with Isoproterenol + Sargassum wightii’s extract. Cardioprotective effects of Sargassum wightii was observed via the changes in the lipid profile, cardio marker enzymes and through histopathological studies. Rats treated with the extract of S. wightii showed a significant reduction in total cholesterol, LDL-cholesterol, serum triglycerides and increase in HDL- cholesterol level indicating an undamaged myocardial membrane. Likewise, low enzyme activity in Sargassum wightii treated rats clearly indicated the cardioprotective effects of Sargassum wightii. Histopathological studies were also done to observe the changes on the rats at the tissue level and no pathological changes were observed in Sargassum wightii treated rats. Hence, methanolic extract of Sargassum wightii is evidenced to possess cardioprotective activity against myocardial infarction.

Keywords

Acute Myocardial Infarction, Cardioprotective Activity, Isoproterenol, Marine Algae, Sargassum wightii.
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  • Cardio Protective Activity of Sargassum wightii on Isoproterenol Induced Myocardial Stress in Rats

Abstract Views: 151  |  PDF Views: 96

Authors

R. E. Renitta
Department of Food Processing Technology, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, Tamil Nadu – 641 114, India
S. Rosario
Department of Biotechnology, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, Tamil Nadu – 641 114, India
P. J. Jane Cypriyana
Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu – 600 119, India
A. V. Samrot
School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP2, Bandar Saujana Putra, 42610, Jenjarom, Selangor, Malaysia
S. Dhiva
Department of Microbiology, Sree Narayana College, Alathur, Palakkad, Kerala – 678 682, India
S. Abirami
Department of Microbiology, Kamaraj College, Thoothukudi, Thirunelveli, Tamil Nadu – 628 003, India
P. Prakash
Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu – 600 119, India

Abstract


The aim of this investigation is to determine whether the methanolic extracts of Sargassum wightii can protect rats against isoproterenol-induced myocardial infarction. Four different groups of rats (6 rats in each group) were taken; where group 1 comprised of normal untreated rats, group 2 was injected with Isoproterenol (synthetic catecholamine), group 3 was considered as standard and hence, was injected with Isoproterenol + Simvastatin and group 4 was treated with Isoproterenol + Sargassum wightii’s extract. Cardioprotective effects of Sargassum wightii was observed via the changes in the lipid profile, cardio marker enzymes and through histopathological studies. Rats treated with the extract of S. wightii showed a significant reduction in total cholesterol, LDL-cholesterol, serum triglycerides and increase in HDL- cholesterol level indicating an undamaged myocardial membrane. Likewise, low enzyme activity in Sargassum wightii treated rats clearly indicated the cardioprotective effects of Sargassum wightii. Histopathological studies were also done to observe the changes on the rats at the tissue level and no pathological changes were observed in Sargassum wightii treated rats. Hence, methanolic extract of Sargassum wightii is evidenced to possess cardioprotective activity against myocardial infarction.

Keywords


Acute Myocardial Infarction, Cardioprotective Activity, Isoproterenol, Marine Algae, Sargassum wightii.

References