Formulation and in-vitro Drug Release for β-cyclodextrin Nanosphears using Emulsification Solvent-evaporation Method

This study gives information about the formulation of β-cylcodextrin nanosphere by emulsification solvent-evaporation method based on emulsifying an organic phase containing the β-cylcodextrin in an aqueous phase of pluronic-F68 as surfactant. The nanospheres are loaded with hydrophobic drug and the in-vitro drug release study was conducted. The formulation of colloidal particle was associated with amphiphilic properties of the β-cylcodextrin derivatives. However, the partitioning of the β- cyclodextrin between the organic and aqueous phases is always depends on the concentration of the surfactant. In the case of nanospheres loaded with Irinotican hydrochloride, the partitioning of the drug occurs between the dispersed phase containing β- cylcodextrin and the continuous aqueous phase containing pluronic-F68.