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Formulation and evaluation of mucoadhesive buccal films of Diclofenac Sodium


Affiliations
1 Shield Health Care Pvt Ltd, Chennai-600095, India
 

Buccal drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form from the buccal cavity. A buccal film for systemic administration of diclofenac sodium has been developed using hydroxyl propyl methylcellulose, poly vinyl pyrolidone, glycerin, eudragit and ethanol by solvent casting method. The prepared films characterized by means of film thickness, swelling capacity, in- vitro adhesion, drug release, weight variation, folding endurance, etc. The in vitro release studies were conducted for diclofenac sodium patches in phosphate buffer-pH-6.6 solution. The mechanism of release is diffusion process followed by first order kinetics. The formulated patches exhibit drug release in the range of 76.92 to 92.12% in four hours.

Keywords

Mucoadhesive Film, Diclofenac Sodium, First Order Kinetics, in- vitro Release
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Abstract Views: 486

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  • Formulation and evaluation of mucoadhesive buccal films of Diclofenac Sodium

Abstract Views: 486  |  PDF Views: 72

Authors

J. Balasubramanian
Shield Health Care Pvt Ltd, Chennai-600095, India
N. Narayanan
Shield Health Care Pvt Ltd, Chennai-600095, India
M. Senthil Kumar
Shield Health Care Pvt Ltd, Chennai-600095, India
M. Vijaya Kumar
Shield Health Care Pvt Ltd, Chennai-600095, India
K. Azhagesh Raj
Shield Health Care Pvt Ltd, Chennai-600095, India

Abstract


Buccal drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form from the buccal cavity. A buccal film for systemic administration of diclofenac sodium has been developed using hydroxyl propyl methylcellulose, poly vinyl pyrolidone, glycerin, eudragit and ethanol by solvent casting method. The prepared films characterized by means of film thickness, swelling capacity, in- vitro adhesion, drug release, weight variation, folding endurance, etc. The in vitro release studies were conducted for diclofenac sodium patches in phosphate buffer-pH-6.6 solution. The mechanism of release is diffusion process followed by first order kinetics. The formulated patches exhibit drug release in the range of 76.92 to 92.12% in four hours.

Keywords


Mucoadhesive Film, Diclofenac Sodium, First Order Kinetics, in- vitro Release

References