Indian Journal of Innovations and Developments

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Objective The effect of vitamins against chloroquine induced hepatoxicity was studied in wistar rats. Analysis of serum AST, ALT and ALP activities with those of total protein and albumin were carried out. Method: Single oral administration of chloroquine (970mg/kg body weight) caused significant increase in AST, ALT and ALP while protein and albumin concentration were reduced. However, simultaneous treatment of chloroquine with 200mg/kg body weight and 4.3 mg/kg of vitamin C and E respectively were administered for 14days. Results: The levels serum AST, ALT and ALP were significantly decreased following the treatment with vitamin C and E. Conclusion: These observations suggest that administration of high dose of chloroquine can cause increase in serum hepatocellular enzymes activities, which is suggestive of liver necrosis which can be ameliorated to varying degrees by vitamins C and E. Hence, fruits rich in vitamin C and E are highly recommended in liver disorders.

Keywords

Hepato-cellular Enzymes, Protein, Chloroquine, Hepatoxicity
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