Indian Journal of Medicine and Healthcare

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Extended spectrum of beta lactamase (ESBL) producing organisms create a major problem in clinical therapeutics. Antimicrobial resistant pattern of uropathogens were isolated from Government hospital, Thiruvanamalai district, Tamilnadu, India, during the period of January to June 2008. Total of 54 ESBL producing clinical isolates of gram negative bacilli were obtained from urine samples of 50 pregnant women. ESBL producers were detected of which 24(44.4%) isolates were E.coli, 20(37%) isolates were K.pneumoniae and 10(18.5%) isolates were P. aeruginosa. Out of 54 isolates 57.4%, 46.6% and 33.3% were resistant to Ampicillin, Amoxycillin and Ceftriaxone respectively. Of all isolates 100% susceptible to Ampicillin, Amoxycillin and Ceftriaxone combined with sulbactum and clavulanic acid showed synergistic effect. These combined drugs were found to be the choice for UTI infection to pregnant women. This study shows the frequency of drug resistant and ESBL producing E. coli, K. pneumoniae and P.aeruginosa is high in pregnant women. Advance drug resistance surveillance of ESBL isolates is need for perceptive use of antimicrobial agents.

Keywords

Uropathogens, UTI, ESBL, Antimicrobial Susceptibility, Drug Resistant
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