Indian Journal of Medicine and Healthcare

The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader).

If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

Fullscreen Fullscreen Off


The effects of Microgynon, a combined oral contraceptive pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol) and Primolut -N, a progestogen only pill (5mg norethisterone) were analysed for their in-vivo effects on rat (<I>rattus rattus</I>) plasma cholesterol and triglycerides. The drugs decreased plasma cholesterol levels in a concentration dependent manner. Microgynon had the most effect, and a highest percentage decrease of 93.33% (0.002 &#177; 0.001 mmol/l (P &#x003C; 0.05)) was observed for the highest dose of 3.6&#956;g/100g body wt. Primolut had lesser effects with figures (0.008 &#177; 0.001 mmo/l and 0.009 &#177; 0.001mmol/l respectively). The drugs increased the levels of triglyceride with Microgynon showing the highest value (0.114 &#177; 0.006 mmol/l). This result indicates that lipoprotein profile are needed for women before using these drugs.

Keywords

Levonorgestrel, Ethinylestradiol, Norethisterone , Cholesterol, Triglycerides
User
Notifications