Indian Journal of NanoScience

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In recent years scientific development has been effected, by overcoming physiological difficulties, in the rate controlled oral drug delivery system such as short gastric residence time and unpredictable gastric emptying time. This review article mostly focuses on the dosage forms which are retained in the stomach for a prolonged and predictable period of time; which are most logical, economical and safest among all approaches to retain the dosage form in the stomach, aimed at enhancing the oral bioavailability of a drug. This study discusses concept of gastric emptying, absorption window, potential drug candidates, technological development evaluation and applications for stomach-specific mucoadhesive nanoparticles. Marketed products for oral nanoparticulate drug delivery systems are also discussed in this review.

Keywords

Gastroretentive, Mucoadhesive, Nanoparticles, Controlled Release, Gastric Residence Time
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