Role of Complement System in Dysbiosis and Periodontal Inflammation―An Overview

Compliment system is tradionally known as a cascade of anti microbial proteins in the blood. It is recognised as a key system for immune surveillance and homeostastis. It has a major link between the innate and the adaptative arms of the host immune response. They exist as pro enzymes and circulate as inactive forms. On activation, they become active, acquire enzymatic or esterase activity, react in particular sequence and cause damage to the neighbouring cells. This review discusses about the dysbiotic transformation of the periodontal pathogens that lead to destructive mechanism and loss of periodontal bone support.