Drug Induced Lichenoid Reactions―A Literature Review

The terms oral lichenoid reactions or oral lichenoid lesions refer to histologically and clinically similar to oral lichen planus. These lesions are described according to the causative factor involved, including direct contact with dental restoration materials, drug-related lesions, and lesions associated to graft-versus-host disease. Drug-induced oral lichenoid reactions were first cited in 1971 by Almeyda and Levantine. Since then, many drug substances have been associated with such lesions. The most common agents are NSAIDs and ACE inhibitors.