Preventing Dental Caries through Microbiome Manipulation

Oral microbiome is natural and has a harmonious relationship with the host by delivering important benefits. But sometimes this dynamic balance gets interrupted either by high sugar intake or low saliva flowwhich decreases the pH level in biofilm. This increases the risk of caries or what we call dysbiosis. Several studies and new insights are put forth to promote symbiosis and prevent dysbiosis. This article focuses on the various method that can achieve our motto i.e. maintenance of equilibrium. Numerous proposed ecologicalapproaches been brought into clinical practice for this purpose. Probiotics, prebiotics,quorumsensing targets, sugar polyols, antimicrobial peptides, replacement therapy with designer bacteria are some of the discussed approaches in the review some of which have undergone successful clinical tests setting milestones in the field of dentistry.