Relationship between Exposure of Cement Dust Emission on Blood Level of Chromium and Nickel as Acarcinogenic Factor of Retinoblastoma

Background: Retinoblastoma is the most commonprimary intraocular malignant tumor in children with genetic etiology. Cement dust is genotoxic and can cause changes in the genetic structure of somatic and germ cells. Cement dust contains metal compounds that are harmful to human health such as chromium and nickel that can enter the human body. Chromium is mutagenic while nickel is a toxic and carcinogenic metal.

Method: This study is analytic cross sectional study in three population groups that are exposed and not exposed to PT. Semen Padang and the group of fathers of children with retinoblastoma. The total sample size is 304 people. Each sample is grouped by sex, occupation, and chromium and nickel levels in the blood.

Results: There were no significant differences in chromium levels of the male and female sample groups (p value 0,598) and no significant differences in the nickel level of the male and female sample groups exposed to cement dust (p value 0.401) . There were no significant differences in chromium levels of the male and female sample groups (p value 0.753) and no significant differences were found in the nickel level of the male and female sample groups not exposed to cement dust, (p value 0.234).

Conclusions: This study showed no statistically significant association between chromium and nickel levels in the blood as carcinogenic substances in retinoblastoma patients to exposure to dust mortar and its

Conclusions: This study showed no statistically significant association between chromium and nickel levels in the blood as carcinogenic substances in retinoblastoma patients to exposure to cement dust and its effects as carcinogenic substances in retinoblastoma disease.