Correlation Between Zinc Level of Mothers and Case of Babies with Non-Syndromic Cleft Lip and Palate

Non-syndromic cleft lip and palate is a common face malformation of all ethnic in population and one of factors caused it was nutritional deficiency. Micronutrient deficiency which mostly occurred in developing countries were Zinc (Zn) and folate acid deficiency. The deficiency of Zn serum in pregnant women was suspected in increasing the complication risk during pregnancy and the deformity risk of non-syndromic cleft lip and cleft palate. This study aimed to analyze the correlation between mother’s zinc level and their babies which suffered with non-syndromic cleft lip and palate, also to determine the median of zinc level among mothers and babies between group of cleft lip, cleft palate, and cleft lip & palate. This was observational and analytical study with cross-sectional design. The participants were 35 babies with Non-syndromic cleft lip and palate and their mother attended the unit of perinatology, Dr. Hasan Sadikin Hospital, Bandung and network hospitals during September 2016-June 2017. The study used consecutive sampling to measured zinc level with ICP-AES (Inductively Coupled Plasma-Atomic Emission Spectrometer) method. The result showed the mean of zinc level among mothers was higher than the babies. The test showed significant correlation (p=0.04 or p<0.05) with the correlation coefficient r=0.35 with term of moderate correlation. There was no difference in median of zinc level among mothers and babies between group of cleft lip, cleft palate, and cleft lip & palate. It concluded that there was moderate correlation between zinc level between mothers and babies with non-syndromic cleft lip and palate.