Indian Journal of Public Health Research & Development

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Protective Effects of Omega3 on CCl4-Induced Oxidative Stress and Nephrotoxicity in Female Albino Rats


Affiliations
1 Medical Technical Institute/Erbil Polytechnic University, Iraq
2 College of Science/Salahaddin University, Iraq
     

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In the present study, twenty one female albino rats were used and they were divided in to three groups. This was carried out and designed to study the effect of omega 3 poly unsaturated fatty acid on carbon tetrachloride (CCl4) induced oxidative stress and kidney damage in female albino rats. However, the antioxidant activity of omega-3 were determined by assessing biochemical parameters (serum creatinine, urea, uric acid, and malondialdehyde (MDA)). Carbon tetrachloride caused significant increase in serum creatinine, urea, uric acid, and MDA level while, omega 3 significantly prevented the increase of the serum levels of creatinine, urea, uric acid, and MDA.

Keywords

Omega-3-Fatty Acids, Carbon Tetrachloride, Free Radicals, Malondialdehyde.
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  • Protective Effects of Omega3 on CCl4-Induced Oxidative Stress and Nephrotoxicity in Female Albino Rats

Abstract Views: 135  |  PDF Views: 0

Authors

Tahseen A. Abdullah
Medical Technical Institute/Erbil Polytechnic University, Iraq
Hawzheen K. Othman
College of Science/Salahaddin University, Iraq

Abstract


In the present study, twenty one female albino rats were used and they were divided in to three groups. This was carried out and designed to study the effect of omega 3 poly unsaturated fatty acid on carbon tetrachloride (CCl4) induced oxidative stress and kidney damage in female albino rats. However, the antioxidant activity of omega-3 were determined by assessing biochemical parameters (serum creatinine, urea, uric acid, and malondialdehyde (MDA)). Carbon tetrachloride caused significant increase in serum creatinine, urea, uric acid, and MDA level while, omega 3 significantly prevented the increase of the serum levels of creatinine, urea, uric acid, and MDA.

Keywords


Omega-3-Fatty Acids, Carbon Tetrachloride, Free Radicals, Malondialdehyde.