Potentials of Nggorang Leaf Standard Extract (Salvia Ccidentalis) Study: Ethnopharmacology, Standardization, Antioxoxide, Sitotoxicity and Working Mechanisms

The use of medicinal plants is used as the main therapy as well as additional therapy to enhance one’s immunity or maintain health and fitness. Nggorang Leaf Extract (EDG) polyphenol and flavonoid compounds and essential oils. Flavonoids are powerful antioxidants that work as a cancer prevention and also have antimicrobial effects. This study aims to prove the potential of EDG as an antioxidant and antiproliferation of Hela cancer cells. This research includes Quasy experiment research The conclusion of this study shows that Nggorang Leaf Extract (EDG) has potential as an antioxidant against DPPH radicals at IC50 = 34,407 ppm; Nggorang Leaf Extract (EDG) has potential as an antiproliferation of T47D IC50 cancer cells = 201 ppm; Nggorang Leaf Extract (EDG) has potential as an antiproliferation of Hela IC50 cancer cells = 187 ppm; Nggorang Leaf Extract (EDG) has the potential to reduce ROS activity in T47D cancer cells by 54.34% at a concentration of 50 ppm; Nggorang Leaf Extract (EDG) has the potential to reduce ROS activity in Hela cancer cells by 58.33% at a concentration of 50 ppm; Nggorang Leaf Extract (EDG) has the potential to increase P53 gene expression in T47D cancer cells by 94.13% at a concentration of 50 ppm; Nggorang Leaf Extract (EDG) has the potential to increase P53 gene expression in Hela cancer cells by 92.05% at a concentration of 50 ppm. The novelty of this study is that Nggorang leaves (Salvia occidentalis) can be used as a preventative for breast cancer and cervical cancer.