ALD Risk Factors and Epidemiology

More than 1 million fatalities are caused worldwide by liver cirrhosis and most of these fatalities are preventable. There is a noticeable geographical variation in mortality levels owing to cirrhosis, and this difference in the burden of liver disease illustrates the connections between the liver disease and mortality population hazards. The varying geographical allocation of significant risk variables for the growth of body illness, including alcohol intake, hepatitis C virus (HCV) infection, hepatitis B virus infection, and obesity and metabolic syndrome, has the ability to highlight possibilities for action, while the evolution of these risk variables offers perspectives into understanding the future burden of liver disease. This study focuses on using population information to define regions and communities at high risk that would profit from preventive measures to decrease liver disease death. To demonstrate the effect these can have if commonly applied, specific policies that are efficient at policy and government health levels are addressed. Also outlined is the effect of therapies that can alter the natural history of liver disease, including immediate antivirals for HCV infection. Finally, the difficulties of explaining non-alcoholic fatty liver disease epidemiology are outlined to demonstrate the need to know the natural history of the disease in order to explain and influence the growth of novel therapies.