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Corn Silk Based Ethosomal Gel: A New Treatment for Periodontitis in Diabetic Albino Rats a Prelimenary Study


Affiliations
1 Oral Biology Department, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia
2 Undergraduate Student Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia
3 Undergraduate Student Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, Indonesia
4 Departement of Public Health Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia
5 Departement of Pediatric Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia
       

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Objective: Periodontitis and diabetes are related and high blood glucose level plays an important part in this correlation. Corn silk has the property of anti‑hyperglycemic and anti‑inflammation. The aim of this study was to determine the capability of corn silk based Ethosomal gel to reduce blood glucose level and degree of inflammation in alloxan induced rats. Material and Method: 15wistar male rats with initial weight of 150gram were included in this study. Alloxan was used to induce diabetes and 5‑0 silk ligatures to induce periodontitis. Blood glucose level was analyzed before and after induction, 3 days after administration, and 7 days after. Degree of inflammation was examined with histopathology test. Results: Blood glucose level in F1 is unstable (p=0.0583>p=0.05), whilst F2 and F3 both showed stable blood glucose decrease (F2: p=0.0086<p=0.05; F3: p=0.035<p=0.05). Anti‑inflammation effects best shown in F3, which has mild inflammation (p=0.001<p=0.05).Whereas both F1 and F2 have moderate inflammation (F1: p=0.225>p=0.05; F2: p=0.423>p=0.05). Conclusion: Corn silk based Ethosomal gel treatment manage to reduce blood glucose level and periodontitis in alloxan induced diabetic rats.

Keywords

Corn silk extract, Diabetes Mellitus, Ethosomal gel, Periodontitis.
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  • Corn Silk Based Ethosomal Gel: A New Treatment for Periodontitis in Diabetic Albino Rats a Prelimenary Study

Abstract Views: 262  |  PDF Views: 0 PDF Views: 0

Authors

Riuwpassa I. E.
Oral Biology Department, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Kim YR
Undergraduate Student Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Tenrilili A.N.A.
Undergraduate Student Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Untung J.S.
Undergraduate Student Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Djamaludin N.S.
Departement of Public Health Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Achmad M.H.
Departement of Pediatric Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Abstract


Objective: Periodontitis and diabetes are related and high blood glucose level plays an important part in this correlation. Corn silk has the property of anti‑hyperglycemic and anti‑inflammation. The aim of this study was to determine the capability of corn silk based Ethosomal gel to reduce blood glucose level and degree of inflammation in alloxan induced rats. Material and Method: 15wistar male rats with initial weight of 150gram were included in this study. Alloxan was used to induce diabetes and 5‑0 silk ligatures to induce periodontitis. Blood glucose level was analyzed before and after induction, 3 days after administration, and 7 days after. Degree of inflammation was examined with histopathology test. Results: Blood glucose level in F1 is unstable (p=0.0583>p=0.05), whilst F2 and F3 both showed stable blood glucose decrease (F2: p=0.0086<p=0.05; F3: p=0.035<p=0.05). Anti‑inflammation effects best shown in F3, which has mild inflammation (p=0.001<p=0.05).Whereas both F1 and F2 have moderate inflammation (F1: p=0.225>p=0.05; F2: p=0.423>p=0.05). Conclusion: Corn silk based Ethosomal gel treatment manage to reduce blood glucose level and periodontitis in alloxan induced diabetic rats.

Keywords


Corn silk extract, Diabetes Mellitus, Ethosomal gel, Periodontitis.



DOI: https://doi.org/10.37506/v11%2Fi1%2F2020%2Fijphrd%2F193951