Corn Silk Based Ethosomal Gel: A New Treatment for Periodontitis in Diabetic Albino Rats a Prelimenary Study

Objective: Periodontitis and diabetes are related and high blood glucose level plays an important part in this correlation. Corn silk has the property of anti‑hyperglycemic and anti‑inflammation. The aim of this study was to determine the capability of corn silk based Ethosomal gel to reduce blood glucose level and degree of inflammation in alloxan induced rats. Material and Method: 15wistar male rats with initial weight of 150gram were included in this study. Alloxan was used to induce diabetes and 5‑0 silk ligatures to induce periodontitis. Blood glucose level was analyzed before and after induction, 3 days after administration, and 7 days after. Degree of inflammation was examined with histopathology test. Results: Blood glucose level in F1 is unstable (p=0.0583>p=0.05), whilst F2 and F3 both showed stable blood glucose decrease (F2: p=0.0086<p=0.05; F3: p=0.035<p=0.05). Anti‑inflammation effects best shown in F3, which has mild inflammation (p=0.001<p=0.05).Whereas both F1 and F2 have moderate inflammation (F1: p=0.225>p=0.05; F2: p=0.423>p=0.05). Conclusion: Corn silk based Ethosomal gel treatment manage to reduce blood glucose level and periodontitis in alloxan induced diabetic rats.