The Role of Matrix Metalloproteinase‑9 (MMP‑9) and Tissue Inhibitor Metalloproteinase‑1 (TIMP‑1) Level in Dengue Hemorrhagic Fever

Introduction: Vascular leakage is a hallmark of Dengue Hemorrhagic Fever (DHF), due to changes in interactions between cells and extracellular matrix in endothelial basement. It major components is type IV collagen that can be destaged by MMP‑9. However, MMP‑9 has an endogenous regulator, TIMP‑1.This study aimed to evaluate between MMP‑9 and TIMP‑1 serum levels in children with DHF. Method: A cross‑sectional study, conducted in Wahidin Sudirohusodo Hospital Makassar, Indonesia. Population of children aged 1 to 18 years from September 2014 to March 2015. Results: Out of 38 subjects, DHF stage I (34,2%), stage II (39,5%), stage III (26,3%) and no stage IV. No significant different levels of MMP‑9 and DHF (P>0.05). There was difference levels of TIMP‑1 in stage I and II (P<0,05). Level of MMP‑9/TIMP‑1 ratio is higher in stage I than II (P<0.05). Positive correlation between MMP‑9 and TIMP‑1 levels in stage II (P<0.05). Conclusion: The levels of MMP‑9 serum could not represent vascular condition in DHF. However, TIMP‑1 serum, MMP‑9/TIMP‑1 ratio, and correlation between the levels of MMP‑9 and TIMP‑1 in DHF describe the vascular state instage I and II.