The Effect of Alkaloid Extract of Teucrium polium L. Against Some Pathogenic Bacteria of Urinary Tracts and on Pyelonephritis Induced in Rats

Objective: In view of the reported literature, the medicinal reputation of T. polium plant stills the researcher’s attention. This study was conducted to evaluate the antibacterial effect of the alkaloid extract of aerial parts of Teucrium polium L. on some pathogenic bacteria and to evaluate the effect of the alkaloid extract in the treatment of induced pyelonephritis in rats.

Method: The aerial parts of Teucrium polium was powdered, extracted with ethanol, filtered, and dried. Antibacterial activity of alkaloid extract (250 mg/mL) was evaluated by agar diffusion method. 24 female rats became pyelonephritis by intraperitoneal injection of Escherichia coli. The animals were divided randomly into four groups. The experimental patients groups received this alkaloid extract and antibiotic gentamycin freely for 10 days but the control group received tap water. Biochemical parameters such as urea and creatinine (CRT) were measured by kinetic (Enzymatic) and colorimetric method.

Results: Our results showed that antibacterial of alkaloid extract gave inhibitory efficacy against the studied bacteria. The results also showed that alkaloid extract can decrease serum urea and creatinine significantly (P<0.05, P<0.001 respectively).

Conclusion: Alkaloid extract of T. Polium have good antibacterial activity and it can be used in the treatment of pyelonephritis instead of antibiotic.