The Effect of Olanzapine on the Improvement of the Clinical Symptom of Schizophrenia

Administration of atypicalantipsychotics (risperidone, olanzapine and clozapine) can improve cognitive dysfunction which occurs in schizophrenia patients. This study was aimed at analyzing the effect of olanzapine on the improvement of clinical symptom (the positive and negative symptoms) in schizophrenia patients. The study was observational with analytic approach on inpatient and outpatient schizophrenia patients in Wahidin Sudirohusodo Hospital and its networking. Subjects comprised of 30 samples who were divided into two groups: the risperidone group which consisted of 15 subjects and the olanzapine group which consisted of 15 subjects. The positive and the negative Symptom Scale (PANSS) wasused to evaluate the psychopathological symptoms. The results showed that improvement of clinical symptom based on the decrease of the positive symptom of thePANSS was significant (p<0.05) since the 2^nd week in both groups. However, comparison of the changes of the positive symptom of the PANSS after medical treatment showed that the decrease of the positive symptom of the PANSS was greater in the risperidone group compared to the olanzapine group (p<0,05). As for negative symptom of the PANSS between the two treatment groups showed that the decrease of negative symptom of the PANSS was significant (p<0.05) since the 2^nd week.