C-Reactive Protein and Soluble Intercellular Adhesion Molecule-1 in Helicobacter Pylori Infection Associated with Chronic Renal Failure

Background: Patients with chronic renal failure have higher risk of Helicobacter pylori infectionas a result of chronic systemic and local circulatory failure, hypergastrinemia, high ammonia and the developed inflammation. Infection with Helicobacter pylori may lead to changes in some inflammatory markers. This study was aimed to investigate the influence of Helicobacter pylori infection onserum levels of C-reactive protein, soluble intercellular adhesion molecule-1 and lipid profile in Iraqi patients with chronic renal failure.

Method: The study included 56 individuals who attended Kirkuk General Hospital to receive hemodialysis. They were divided into 2 groups; chronic renal failure patients with Helicobacter pylori seropositive (Group 1) and seronegative (Group 2) infections. Group 3 included 30 apparently healthy subjects as control group who were age- and gender-matched to patients groups. Lipid profiles were measured by enzymatic analytical chemistry. C-reactive protein, soluble intercellular adhesion molecule-1 and anti Helicobacter pylori IgG were assayed by ELISA technique.

Results: When we compared chronic renal failure patients with Helicobacter pylori seropositive and seronegative infections to healthy normal renal function subjects, we found significant increase in C-reactive protein and soluble intracellular adhesion molecule-1 levels, whilst there were no significant differences between Helicobacter pylori seropositive and seronegative chronic renal failure patients (P>0.05). In this regard, lipid profile results showed a significant reduction in total cholesterol and High density lipoprotein levels inpatients. Also, linear correlation was found between soluble intracellular adhesion molecule-1 level and creatinine.

Conclusion: The result of this study concluded that impaired renal function is associated with endothelial dysfunction and raised inflammatory activity as assessed by serum levels of soluble intracellular adhesion molecule-1 and C-reactive protein as well as urea and creatinine levels, yet these patients had reduction in lipid profile as a result of malnutrition. However, Helicobacter pylori infection didn’t induce significant changes in the levels of studied parameters which are considered important risk factors for atherosclerosis.