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Significance of PD-L1 Expression and Tumor Infiltrating Lymphocytes in High Grade Serous Ovarian Cancer:Egyptian Experience
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We aimed in this study to detect the correlation between PD-L1 and TILs, and their relationship with clinical outcome and survival in Egyptian patients with HGSOC.
Immunohistochemical expression of PD-L1, CD4 and CD8 was investigated in 94 HGSOC Egyptian patients. PD-L1 immunoreactivity was detected in 24% of the cases. The lack of tumor PD-L1 expression proved to be an independent predictive factor for better overall survival (OS) (p=0.01). Moreover, high stromal CD8 + TILs density had a significant impact on better disease-free survival (p=0.007). Patients who showed negative expression of PD-L1 and high intraepithelial CD8+ TILs density lived significantly longer than other patients (p=0.021).
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