Evaluation the Effect of a Different Beta Blockers Agents on Somebody Metabolic Parameters in Patients with Essential Hypertension

Background: Hypertension is a common disease characterized by elevation of blood pressure above normal levels .The causes of Hypertension in most individuals cannot actually be determined. It is termed essential hypertension. Initial treatment of Hypertension to decrease blood pressure includes modification of lifestyle and medication. Beta-blockers is the most important antihypertensive agent that is accepted as a first-line antihypertensive agent, but may exert side effects on lipid and glucose metabolism, glucose tolerance and weight.

Method: The study was carried out on 60 individuals; Divided into three groups (A, B and C), they consisted of 20 individuals for each group (10 males + 10 females). Three Beta-blockers agents were attended in this study: Propranolol 40 mg for group A, Atenolol 50 mg for group B and nebivolol 5 mg for group C. Systolic, diastolic blood pressure, pulse, HbA1c, Lipid Profile and BMI measured at two interval first at starting treatment second 3 months later.

Results: Results of group A showed significant decrease of pulse, SBP, DBP, HDL-c, high significant increase in AI, significant increase in HbA1c, TG,VLDL-c, BMI. No significant of TC and LDL-c. While the results of group B show significant decrease of pulse, SBP, DBP, and HDL-c, significant increase in HbA1c, TG, VLDL-C, AI and BMI. No significant of TC and LDL-c. whereas results of group C showed a significant decrease in SBP, DBP and pulse, all other metabolic profiles showed no significant changes.

Conclusion: The current study concluded that Propronalol 40 mg Atenolol 50 mg and Nebivolol 5 mg were effective antihypertensive that decrease SBP, DBP, Heart rate with Nebivolol have favorable action on metabolic profile, Propronalol and Atenololcauseun favorable action on metabolic profile, but still used as antihypertensive.