Indian Journal of Public Health Research & Development

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Evaluation of an Experimental Poly-Methyl Methacrylate/Nano Graphene Oxide Composite


Affiliations
1 Biomaterials Department, Faculty of Dentistry, Minia University, Minia, Egypt
2 Professor of Dental Materials, Minia University, Minia, Egypt
3 Bio-Medical Engineering Department, Faculty of Engineering, Minia University, Minia, Egypt
     

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Aim: This study was conducted to establish a standard mixing protocol of nano graphene oxide (GO) incorporated into poly-methyl methacrylate (PMMA) to form GO/PMMA composite. Different concentrations of these composite were evaluated for biocompatibility.

Method: Three different mixing protocols were done to select optimum one to incorporate GO into commercially available PMMA. In the first protocol GO powder incorporated into PMMA powder. In the second protocol GO powder incorporated into methyl methacrylate (MMA) monomer. While in the third protocol PMMA powder incorporated into GO water dispersion. The most homogeneous protocol was the third one which was used to formulate GO/PMMA composite in a five concentrations 0%, 0.05%, 0.1%, 0.15% and 1% to form groups I-V respectively. For biocompatibility determination rabbit hemolysis test was used.

Results: The percent of hemolysis were less than 5% for all groups tested in rabbit hemolysis test.

Conclusions: GO/PMMA composite is biocompatible.


Keywords

Graphene Oxide, PMMA, Mixing, Hemolysis.
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  • Evaluation of an Experimental Poly-Methyl Methacrylate/Nano Graphene Oxide Composite

Abstract Views: 368  |  PDF Views: 0

Authors

Reem Gamal
Biomaterials Department, Faculty of Dentistry, Minia University, Minia, Egypt
Yasser F. Gomaa
Professor of Dental Materials, Minia University, Minia, Egypt
Ashraf Mahroos
Bio-Medical Engineering Department, Faculty of Engineering, Minia University, Minia, Egypt

Abstract


Aim: This study was conducted to establish a standard mixing protocol of nano graphene oxide (GO) incorporated into poly-methyl methacrylate (PMMA) to form GO/PMMA composite. Different concentrations of these composite were evaluated for biocompatibility.

Method: Three different mixing protocols were done to select optimum one to incorporate GO into commercially available PMMA. In the first protocol GO powder incorporated into PMMA powder. In the second protocol GO powder incorporated into methyl methacrylate (MMA) monomer. While in the third protocol PMMA powder incorporated into GO water dispersion. The most homogeneous protocol was the third one which was used to formulate GO/PMMA composite in a five concentrations 0%, 0.05%, 0.1%, 0.15% and 1% to form groups I-V respectively. For biocompatibility determination rabbit hemolysis test was used.

Results: The percent of hemolysis were less than 5% for all groups tested in rabbit hemolysis test.

Conclusions: GO/PMMA composite is biocompatible.


Keywords


Graphene Oxide, PMMA, Mixing, Hemolysis.



DOI: https://doi.org/10.37506/v11%2Fi1%2F2020%2Fijphrd%2F194144