Indian Journal of Public Health Research & Development

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Oral Mucoadhesive Drug Administration-A Short Review


Affiliations
1 Post Graduate Student, Department of Oral Pathology and Microbiology Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, India
2 Professor, Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, India
3 Reader, Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, India
4 Professor and Head of the Department, Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, India
     

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On focus with route of drug administration, the oral cavity is an attractive and the safest site for the delivery of drugs. As an advantage it can overcome acidic environment thereby causing instability of the drug, extensive first pass metabolism and low bioavailability of drug results an inadequate absorption. The buccal mucosa is rich in blood supply and relatively permeable. Buccal cavity was found to be most accessible site for both local and systemic delivery of drug. This review presents a brief description of advantages and limitations of oral mucosal drug delivery, mechanisms of drug permeation followed by current developments in this drug delivery systems.

Keywords

Drug, Buccal, Sublingual.
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  • Oral Mucoadhesive Drug Administration-A Short Review

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Authors

P. Sangeetha Priya
Post Graduate Student, Department of Oral Pathology and Microbiology Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, India
N. Aravindha Babu
Professor, Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, India
N. Anitha
Reader, Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, India
K. M. K. Masthan
Professor and Head of the Department, Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, India

Abstract


On focus with route of drug administration, the oral cavity is an attractive and the safest site for the delivery of drugs. As an advantage it can overcome acidic environment thereby causing instability of the drug, extensive first pass metabolism and low bioavailability of drug results an inadequate absorption. The buccal mucosa is rich in blood supply and relatively permeable. Buccal cavity was found to be most accessible site for both local and systemic delivery of drug. This review presents a brief description of advantages and limitations of oral mucosal drug delivery, mechanisms of drug permeation followed by current developments in this drug delivery systems.

Keywords


Drug, Buccal, Sublingual.