Comparative Evaluation of Periodontal Status and II-6 Levels in Chronic Kidney Disease Patients and Healthy Individuals

Background: Chronic kidney disease (CKD) is a veryreal and growing problem, as indicated by demographic trends. Presence of undiagnosed periodontitis may have significant effect on the medical management of CKD patient as its been found to contribute to systemic inflammatory burden.This study evaluate and compare the periodontal status and IL-6 levels among CKD, periodontitis and Healthy patients.

Materials and Method: Whole serum samples werecollected from 80 patients who were further divided into four groups; healthy (n=20), periodontitis (n=20), HD (n=20), PD (n=20). Serum IL-6 concentrations were determined by Standard enzyme -linked immunosorbent assay.

Results: Indicates the IL-6 levels in the studypopulation. The mean IL-6 value being highest in pre-dialysis (92.695) compared to dialysis (53.112), periodontitis (9.22) and healthy individuals (9.6). ANOVA results show a significant increase of IL-6 levels in the pre-dialysis group compared to alter groups. No significant change on PPD was appreciated.

Conclusion: Treatment of moderate to severeperiodontitis in ESRD populations will result in decreased IL-6 levels and, more importantly, decreased incidence of atherosclerotic complications awaits the result of interceptive clinical trials in this population