Indian Journal of Public Health Research & Development

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Prevalence, Contributing Factors and Clinical Characteristics of Dyslipidemia in Children with Type 1 Diabetes


Affiliations
1 Pediatric Department, Faculty of Medicine, Kafrelsheikh University, Kafr Elsheikh, Egypt
2 Pediatric Endocrinology Units, Faculty of Medicine, Cairo University, Egypt
3 Pediatric Gastroenterology Unit, Faculty of Medicine, Cairo University, Egypt
     

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Background: Achieving ideal goals of glycemic control in children and adolescents with type 1 diabetes (T1D) is challenging. One of the commonest adverse effects of poor control is dyslipedemia with the subsequent cardiovascular events in young adulthood.

Aim: This study investigates the prevalence of lipoprotein disorders in children with T1D and studies its possible causes.

Materials and Method: We recruited 80 type 1 diabetic child, took full history and assessed them clinically for their status of growth and puberty. Biochemical analysis including glycated hemoglobin (HbA1c) and lipoprotein profiles was done.

Results: Abnormal lipid profiles were detected in 33% and poor glycemic control in 85% of our studied patients.The group of patients with better glycemiccontrol had a significant elevation of HDL-c and a significant reduction of TG levels than those with poor control. Moreover the group of patients who did not have dyslipdemia had a significant reduction in HbA1c level.

Conclusion: Dyslipedemia is highly prevalent in diabetic children. Poor glycemic control is a strong contributing factor. Early recognition and intervention is fundamental for the prevention of its harmful sequences. Further studies are warranted to asses the effect of improving glycemic control on the status of dyslipedemia in diabetic children.


Keywords

Dyslipedemia, T1D, Children.
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  • Prevalence, Contributing Factors and Clinical Characteristics of Dyslipidemia in Children with Type 1 Diabetes

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Authors

Shaimaa Salah
Pediatric Department, Faculty of Medicine, Kafrelsheikh University, Kafr Elsheikh, Egypt
Dina Khedr
Pediatric Endocrinology Units, Faculty of Medicine, Cairo University, Egypt
Amera Hasnoon
Pediatric Gastroenterology Unit, Faculty of Medicine, Cairo University, Egypt

Abstract


Background: Achieving ideal goals of glycemic control in children and adolescents with type 1 diabetes (T1D) is challenging. One of the commonest adverse effects of poor control is dyslipedemia with the subsequent cardiovascular events in young adulthood.

Aim: This study investigates the prevalence of lipoprotein disorders in children with T1D and studies its possible causes.

Materials and Method: We recruited 80 type 1 diabetic child, took full history and assessed them clinically for their status of growth and puberty. Biochemical analysis including glycated hemoglobin (HbA1c) and lipoprotein profiles was done.

Results: Abnormal lipid profiles were detected in 33% and poor glycemic control in 85% of our studied patients.The group of patients with better glycemiccontrol had a significant elevation of HDL-c and a significant reduction of TG levels than those with poor control. Moreover the group of patients who did not have dyslipdemia had a significant reduction in HbA1c level.

Conclusion: Dyslipedemia is highly prevalent in diabetic children. Poor glycemic control is a strong contributing factor. Early recognition and intervention is fundamental for the prevention of its harmful sequences. Further studies are warranted to asses the effect of improving glycemic control on the status of dyslipedemia in diabetic children.


Keywords


Dyslipedemia, T1D, Children.