Gynaecological Manifestations of Systemic Malignancies

Context: Round cell tumours and haematolymphoid malignancies presenting with gynaecological symptoms are not infrequent. Often, those are a component of a symptom complex which has a clue towards the aetiology. Round cell tumours or haematolymphoid malignancies presenting solely as structural lesions of the female genital tract are really uncommon. A series of 10 such cases are depicted here.

Aims:

1. To study the epidemiological pattern among these patients

2. To assess the prognosis of such cases.

Settings and Design: Single institutional observational study.

Method and Material: Cases were selected from the case record files and data collected. CT scan of (Thorax + Abdomen + Pelvis)was done in all cases. The diagnosis was established by histopathology and immunohistochemistry in each case.

Statistical Analysis Used: Descriptive statistics used for analysis.

Results: Median age of presentation was 25 years. Median duration of symptoms was 3 months, most commonly pain abdomen. Fallopian tubes and ovaries were involved in 90% cases, with pelvic and retroperitoneal lymphadenopathy in 80% cases. Majority of the underlying malignancies were haematolymphoid malignancies.

Conclusions: Clue to suspicion of underlying round cell tumours or haematolymphoid malignancies are younger age, mass lesion of uterus and adnexa, regional lymphadenopathy and absence of ascites. Earlydiagnosis is necessary since the above group of diseases represent curable malignancies even at advanced stages so we need to treat before their performance score deteriorates.