Associations Between TNF-α and Interleukin-18 and ADIPOQ Gene Polymorphisms in Iraqi Obese Women Patients with Polycystic Ovary Syndrome

Context: Polycystic ovary syndrome has always been an enigma, and it still continues to be. In addition to an ovulatory subfertility, women with PCOS show an increased danger of pregnancy complications, obesity, so the effect of this issue isn’t simply constrained to reproductive age, however all through life. A total of (128) samples (50 normal Weight and 78 obese groups). Those samples was collected from the Kamal Al-Samarraie hospital, Ministry-of Health in Baghdad-Iraq from April 2017-August 2017. The aim of this present study to was to detect association from polymorphism ADIPOQ gene (rs12495941) with risk of Polycystic ovary syndrome for Iraqi women patients and compare between ADIPOQ gene of Iraq population with gene bank of NCBI. Examine Interleukin-18(IL-18), Tumor necrosis factor alpha (TNF-α) of Polycystic ovary syndrome Iraqi women patients. TNF-α, and IL-18 showed significantly change(p<0.05) in Obese with PCOS and low weight with PCOS groups when comparing with control group. followed by no-significant change (p>0.05)when comparing between Obese without PCOS and low weight with PCOS groups, also shows significant change(p<0.05)when comparing between low weight with PCOS and control group.The results show substitution three Transition A>G and G>A, six Transversion T>G, T>A, and C>A, showed 98% identified with a standard in Gene Bank from patients group while having 100% identified with a standard in Gene Bank with the control group.