HIV and Zonke-bonke Syndrome in Mthatha Region of South Africa: Case Reports

Introduction: South Africa is an African rainbow nation, not only in its color of population, but also in the mixture of HIV infection. There is all three combinations are of HIV infection such as HIV-1, HIV-2, and both of them. This is matter of concern. Objective: To highlight the problem of HIV-1 and HIV-2 (combined) infection in Mthatha region of South Africa. Case History: First time four cases of HIV-1/2, mixed infection were reported within period of 1-year (2009). They were reported at Sinawe Center for examination for their sexually assaulted. The HIV screening tests were carried out for HIV infection. There were four patients were found positive for both HIV1 & 2. Surprisingly, one was a child of 8-years of age. Multiple sexual partners some or other time crossed with West African who were harboring the type 2 HIV could be the cause of this mixed infection. This kind of promiscuous behavior with multiple partners is called as “Zonke-bonke syndrome”. The history, mode of transmission of HIV infection, and the consequences of mixed HIV infections is discussed in this case reports. Conclusion: There is prevalence of HIV-1 & HIV-2 (mixed) infection in Mthatha region of South Africa. It is a serious matter of concern.