MCP-1 Serum Levels were Higher in Patient with Diabetic Nephropathy among Balinese

Background and Aim: Diabetic nephropathy is a complication of diabetes mellitus which can lead to kidney failure. Monocyte Chemoattractant Protein-1 (MCP-1) is a protein that is expected to be a biomarker of diabetic nephropathy. The purpose of this study was to examined the relationship of MCP-1 with diabetic nephropathy in Indonesia, especially in Bali therefore the accuracy in detecting diabetic nephropathy can be assessed. Method: One hundred and sixteen patients with type 2 diabetes mellitus with diabetic nephropathy (n = 37) and without diabetic nephropathy (n = 79) were included in this study. MCP-1 serum was examined using the enzyme-linked immunosorbent assay (ELISA) method. Result: MCP-1 serum levels were significantly higher in patients with diabetic nephropathy (p <0.001). Analysis of receiver operating characteristic (ROC) curve for diabetic nephropathy detection showed that cut-off point of MCP-1 serum was 436 pg/ml with a sensitivity of 83.7% and 84.8% specificity. Conclusion: It can be concluded that MCP-1serum can be considered as a biomarker for detection of diabetic nephropathy.