Neurological And Non Neurological Role of Brain-Derived Neurotrophic Factor (BDNF) in Developing Jaw

Background: Brain-derived neurotrophic factor (BDNF), recognized to be involved in differentiation and proliferation of specialized cell such as endothelial cell and osteoblast cell. Aim of the Study: The study was designed to identify the effect of exogenous BDNF on development of jaw and on neural marker expression. Materials and Method: Twenty pregnant rats,ten injected (I.M) with normal saline,other ten injected (I.M) with 0.1 ml of BDNF that received three doses at intervals (0,7,14 day of gestation period).Embryos at 16^th and 18^th intra-uterine life were used for histological and immunohistochemical evaluation for the development of prenatal jaw. Results: Illustrate an enhancement of bone development during proceeding embryonic periods for both study groups .Moreover, the experimental group shows a high significant difference in the mean of bone cell count at the period 18^th day in comparisum to 16^th day IUL,and in comparisum to control at 18^th day IUL. Results show positive expression of neuronal marker by proliferating nerve cells in control and experimental groups with significant difference. Conclusion: The study suggest that BDNF contributes to promoting the differentiation of bone cells and enhancement of bone formation by increasing expression of neuron marker.