Lapin Stealth Citrobacter Urogenital Infection Model

A lapin stealth C.freundii urogenital infection models were being developed. Three groups each of five rabbits were assigned as group I for stealth C.freundii, group II for intact C.freundii and group III for control. The infectious dose was rated to, 1x10 to 7 CFU/ml. The dosing program was through transurethral route. From the time zero day up to the day eight post infection the rabbits was watched for signs of disease. The changes in the whole animal beings were found as; rise up in body temperature, loss of appetite, loss of body weight and sluggishness .Postmortem gross urogenital organ/tissue matrix changes were congestion and haemorrhage. Tissue changes were noted as an acute to sub-acute urethritis,cystitis and testiculitis. To this end rabbits were proved to be suitable experimental models for evidence of stealth C.freundii pathogenicity. The developed models are being novel so far C.freundii is concerned.