Microscopic Vision of an Experimental Infection Effect with Candida Glabratayeast in the Histological Structure of the Heart and Lungs in Immunosuppressed Male Mice and Other Normal Mice

The research was conducted to study histological structure of heart and lungs in male mice after being experimentally infected with Candida glabrata yeast isolated from the patient visitors of Tikrit Teaching Hospital suffering from Invasive Candidiasis (38 males, 25 females) between the ages of 15 and 82 years. The results showed pathological histological changes in both heart and lungs of male mice experimentally infected with the C. glabrata inhibitory immunosuppressant, which consisted of sloughing the basal membrane of the endocardium, as well as sarcoplasm degeneration of myocardial cells. In lungs the histological sections showed occurrence of extensive hemorrhage in and around alveoli and emergence of lymphocytes around the bronchioles as well as congestion and bleeding of blood vessels. While the results of the normal mice group (non-immunosuppressant) showed pathological histological changes represented by the local degeneration of heart sarcoplasm muscle, and in lungs have shown severe congestion of blood vessels and capillaries around alveoli as well as emergence of RBCs and desquamation of epithelial cells in the trachea with a local lymphocytic aggregation compared to the control group.