Hypothyroidism, Prolactin and Function of the Pituitary-Gonadal Axis in Iraqi Patients with Chronic Kidney Disease

The present study was aimed to examine the associations among chronic kidney disease(CKD) and hormonal status byevaluation levels of: Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH), Prolactin,Estrogen (E2) and Progesterone (P4)for females and Testosterone for males along with thyroid hormones (TSH, T3, andT4) in CKD patients. The study included 50 patients who are diagnosed to have CKD stage-5, their ages ranged between 20-50 years (25 males and 25 females) who attended the Nephrology and Transplant Center in Medical City of Baghdad- Iraq from April 2018 to July 2018, and 20 matched apparently healthy as control, their ages ranged between 20-48 years (10 males and 10 females). The study showed a highly significant (P<0.01) increase in LH, FSH levels in CKD patients compared to the control group. Highly significant (P<0.01) increase in Prolactin level as compared to healthy individuals and highly significant (P<0.01) decrease in E2 level in CKD females patients compared to the control group, while there was non-significant (P>0.05) decrease in P4 level in CKD female patients compared to the control group. On the other hand there is significant (P<0.05) decrease in Testosterone level in CKD males patients compared to the control group. In parallel TSH was recorded a highly significant (P<0.01) increase in CKD patients in comparison with control. While T3 and T4 levels highly significant (P<0.01) decrease in CKD patients in comparison with control.