Treatment Options of Peyronie’s Disease

Objective:Peyronie’s disease (PD) is a localized fibrous scar in the tunica albuginea of the penis resulting in a palpable penile plaque, penile pain on erection, penile curvature and erectile dysfunction. This study evaluated our own experience with clinical outcomes after different method of treatment for PD.

Patients and Method:The study included 62 patients with PD aged from 33-72 years. Two groups of patients were evaluated, the first one (Non-surgical) included 44 patients, 30 of them treated with oral therapy and 14 patients had intralesional Verapamil injection. The second group (Surgical) included 18 patients, 10 had plication of the tunica albuginea in the contralateral side of the fibrous plaque, and 8 patients had penile prosthesis implantation.

Results:Oral therapy associated with improvement of penile bending in 50% and improvement of painful erection in 40%. Intralesional Verapamil injection results in improvement of penile bending was 56% and improvement of painful erection 70%. The plication of the tunica albuginea results in improvement of penile bending 80%, improvement of painful erection 70% and improvement of erectile function 60%. With penile prosthesis implantation, all patients had improvement of penile bending and 83% of them had improvement of painful erection. Post-operative patient’s satisfaction increased gradually by time from 3 to 9 months.

Conclusion:The proper choice of treatment for PD affects its outcome. For surgery, the preferred option is plication in mild to moderate deformities with considerable penile length while penile prosthesis is reserved for patients with erectile dysfunction.