Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Three Year Retrospective Study of Carcinoma of Breast in Young Females at Davangere


Affiliations
1 Department of General Surgery, SSIMSRC, Davanagere, Karnataka, India
     

   Subscribe/Renew Journal


Background: Carcinoma of the breast is the most common cancer in women in many of the western countries and becoming the leading cancer in developing countries such as India. Cancer breast in women younger than 30 years of age is rare and is particularly of more concern because of the special considerations such as pregnancy, fertility and sexuality.

Objective: The objective of this study is to evaluate the incidence of cancer breast in women aged less than 30 years and to study the prognostic factors in patients treated in our institute and to compare the same with national and international statistics.

Methods: cancer breast statistics was collected from the medical records department of our institute, the pathological data concerning the type of tumor, stage, grade, lymphnode involvement was collected from the department of pathology and the data was tabulated, evaluated and compared with the national and international statistics.

Results: in our study the incidence of cancer breast in 30 years and less than 30 years of age is 4.67% with the mean age of 27+/-3.8, mean tumour size was 4.4+/-1.2cms, lymph node metastasis was seen in 60% of patients, mean number of lymph nodes positive for metastasis was 6.14+/-1.87, most common histological type of tumour being infiltrating ductal carcinoma (60%) and the most common histological grade was grade 2 in 60% of patients.

Conclusion: carcinoma of breast is quite commoner in young women less than 30 years and has got an unfavourable prognosis and hence the diagnosis has to be kept in mind while evaluating for a breast lump in younger patients.


Subscription Login to verify subscription
User
Notifications
Font Size


  • Althuis MD, Dozier JM, Anderson WF, Devesa SS, Brinton LA. Global trends in breast cancer incidence and mortality 1973-1997. Int J Epidemiol 2005;34:405-412.

  • Murthy NS, Chaudhry K, Nadayil D, Agarwal UK, Saxena S. Changing trends in incidence of breast cancer: Indian scenario. Indian J Cancer 2009;46:73-74.

  • Brinton LA, Sherman ME, Carreon JD, Anderson WF. Recent trends in breast cancer among younger women in the United States. J Natl Cancer Inst, 100, 1643-1648.

  • Pagani O, O’Neill A, Castiglione M, et al (1998). Prognostic impact of amenorrhoea after adjuvant chemotherapy in premenopausal breast cancer patients with axillary node involvement: results of the International Breast Cancer Study Group (IBCSG) Trial VI. Eur J Cancer, 34, 632-640.

  • Siddiqui N, Siddique MK, Muazzam IA, et al (2008). Breast cancer in very young Pakistani women at a cancer hospital in Lahore. J Clin Oncol, 26, 11596.

  • Krystal Bottom, MD, Maura O’Leary, MD, Jan Sheaffer, BA, Marianne Phillips, MBCHB, MD, Xiao-Ou Shu, PhD, Banu Arun, MD. Breast Cancer. SEER AYA monograph, National Cancer Institute.pp.111-121.

  • Ries LAG, Melbert D, Krapcho M, et al., eds. SEER Cancer Statistics Review, 1975-2004, National Cancer Institute. Bethesda, MD,http:// seer.cancer.gov/csr/1975_2004/, based on November 2006 SEER data submission, posted to the SEER Website, 2007.

  • Goldhirsch A, Gelber RD, Yothers G, et al. Adjuvant therapy for very young women with breast cancer: need for tailored treatments. J Natl Cancer Inst Monogr. 2001(30):44-51.

  • Kroman N, Jensen MB, Wohlfahrt J, Mouridsen HT, Andersen PK, Melbye M. Factors influencing the effect of age on prognosis in breast cancer: population based study. BMJ. Feb 19 2000;320(7233):474-478.

  • Talley LI, Grizzle WE, Waterbor JW, Brown D, Weiss H, Frost AR. Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre- and postmenopausal women. Int J Cancer. Mar 1 2002;98(1):118-127.

  • Anders CK, Hsu SD, Acharya CR, et. al. Molecular signatures characterize early stage breast cancer arising in young women and have prognostic and therapeutic implications independent of ER status. Paper presented at: Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S ( June 20 Supplement), 2007: 522.

  • Nadira Mamoon, Usman Hassan, Sajid Mushtaq Breast Carcinoma in Young Women Aged 30 or Less in Northern Pakistan - the Armed Forces Institute of Pathology Experience. Asian Pacific J Cancer Prev, 10, 1079-1082.

  • American cancer society, Breast cancer Facts and figures, 2008-2009.

  • Horner MJ, Ries LAG, Krapcho M, et al (2009). SEER Cancer Statistics Review, 1975-2006, National Cancer Institute. Bethesda, MD, http:// seer.cancer.gov/csr/1975_2006/, based on November 2008 SEER data submission.

  • Kroman N, Melbye H, Mouridsen HT (2002). Prognostic influence of age at diagnosis in premenopausal breast cancer patients. Scand J Surg, 91, 305-308.

  • Pharoah PD, Lipscombe JM, Redman KL, et al (2000). Familial predisposition to breast cancer in a British population: implications for prevention. Eur J Cancer, 36, 773-779.

  • Brennan M, French J, Houssami M, Kirk J, Boyages J (2005). Breast cancer in young women. Aust Fam Phys, 34, 851-855.

  • Hickey M, Peate M, Saunders CM, Friedlander M (2009). Breast cancer in young women and its impact on reproductive function. Human Reproduction Update, 15, 323-339.

  • Anyanwu S . Temporal trends in breast cancer presentation in the third world. J Exp Clin Cancer Res,2008, 27, 17.

  • Tabbane F, May A, Hachiche M, et al (1985). Breast cancer in women under 30 years of age. Breast Cancer Res Treat, 6, 137-44.

  • Siddiqui N, Siddique MK, Muazzam IA, et al (2008). Breast cancer in very young Pakistani women at a cancer hospital in Lahore. J Clin Oncol, 26, 11596.

  • Szabo CI, King MC. Population genetics of BRCA1 and BRCA2. Am J Hum Genet 1997;60:1013-1020.

  • Struewing JP, Hartge P, Wacholder S, Baker SM, Berlin M, McAdams M, et al. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med 1997;336:1401-1408.

  • Anglian Breast Cancer Study Group. Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Br J Cancer 2000;83:1301-1308.

  • Hopper JL, Southey MC, Dite GS, Jolley DJ, Giles GG, McCredie MR, et al. Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of proteintruncating mutations in BRCA1 and BRCA2. Australian Breast Cancer Family Study. Cancer Epidemiol Biomarkers Prev 1999;8:741-747.

  • Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 1998;62:676-689.

  • Rennert G, Dishon S, Rennert HS, Fares F. Phenotypic characteristics of families with BRCA1 and BRCA2 mutations in Israel. Eur J Cancer Prev 2005;14:357-3561.

  • Gad Rennert, Breast Cancer, Chapter 8, MECC monograph, pp 73-80.

  • Hawwas AW. Breast feeding as seen by Islam. Popul Sci 1987;7:55-8.

  • Goldhirsch A, Gelber RD, Yothers G, et al. Adjuvant therapy for very young women with breast cancer: need for tailored treatments. J Natl Cancer Inst Monogr. 2001(30):44-51.

  • Kroman N, Jensen MB, Wohlfahrt J, Mouridsen HT, Andersen PK, Melbye M. Factors influencing the effect of age on prognosis in breast cancer: population based study. BMJ. Feb 19 2000;320(7233):474-478.

  • Talley LI, Grizzle WE, Waterbor JW, Brown D, Weiss H, Frost AR. Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre- and postmenopausal women. Int J Cancer. Mar 1 2002;98(1):118-127.

  • Anders CK, Hsu SD, Acharya CR, et. al. Molecular signatures characterize early stage breast cancer arising in young women and have prognostic and therapeutic implications independent of ER status. Paper presented at: Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S ( June 20 Supplement), 2007: 522.)

  • Daling JR, Malone KE, Doody DR, Anderson BO, Porter PL. The relation of reproductive factors to mortality from breast cancer. Cancer Epidemiol Biomarkers Prev. 2002; 11: 235–241.

  • Kroman N, Wohlfahrt J, Andersen KW, Mouridsen HT, Westergaard T, Melbye M. Time since childbirth and prognosis in primary breast cancer: population based study. BMJ. 1997; 315: 851–855.

  • Olson SH, Zauber AG, Tang J, Harlap S. Relation of time since last birth and parity to survival of young women with breast cancer. Epidemiology. 1998; 9: 669–671.)

  • Sankila R, Heinavaara S, Hakulinen T. Survival of breast cancer patients after subsequent term pregnancy. “Healthy mother effect.” Am J Obstet Gynecol. 1994; 170: 818–823.

  • Kroman N, Jensen J-J, Melbye M, Wohlfahrt J, Mouridsen HT. Should women be advised against pregnancy after breast cancer treatment? Lancet. 1997; 350: 319–322.

  • Velentgas P, Daling JR, Malone KE, et al. Pregnancy after breast carcinoma: outcomes and influence on mortality. Cancer. 1999; 85: 2424–2432.


Abstract Views: 445

PDF Views: 0




  • A Three Year Retrospective Study of Carcinoma of Breast in Young Females at Davangere

Abstract Views: 445  |  PDF Views: 0

Authors

T Zameer Ulla
Department of General Surgery, SSIMSRC, Davanagere, Karnataka, India

Abstract


Background: Carcinoma of the breast is the most common cancer in women in many of the western countries and becoming the leading cancer in developing countries such as India. Cancer breast in women younger than 30 years of age is rare and is particularly of more concern because of the special considerations such as pregnancy, fertility and sexuality.

Objective: The objective of this study is to evaluate the incidence of cancer breast in women aged less than 30 years and to study the prognostic factors in patients treated in our institute and to compare the same with national and international statistics.

Methods: cancer breast statistics was collected from the medical records department of our institute, the pathological data concerning the type of tumor, stage, grade, lymphnode involvement was collected from the department of pathology and the data was tabulated, evaluated and compared with the national and international statistics.

Results: in our study the incidence of cancer breast in 30 years and less than 30 years of age is 4.67% with the mean age of 27+/-3.8, mean tumour size was 4.4+/-1.2cms, lymph node metastasis was seen in 60% of patients, mean number of lymph nodes positive for metastasis was 6.14+/-1.87, most common histological type of tumour being infiltrating ductal carcinoma (60%) and the most common histological grade was grade 2 in 60% of patients.

Conclusion: carcinoma of breast is quite commoner in young women less than 30 years and has got an unfavourable prognosis and hence the diagnosis has to be kept in mind while evaluating for a breast lump in younger patients.


References