Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Study of Thyroid Function Tests in Pregnant and Non - Pregnant Women in the Reproductive Age Group of the Garhwal Region of Uttarakhand - India


Affiliations
1 Dept of Biochemistry, VCSG Govt Medical Science & Research Institute, Srikot, Srinagar (Pauri), Uttarakhand, India
2 Dept of Community Medicine, VCSG Govt Medical Science & Research Institute, Srikot, Srinagar (Pauri), Uttarakhand, India
     

   Subscribe/Renew Journal


Background: Pregnancy is associated with significant but reversible changes in thyroid function tests which are among the most profound to be seen as a result of a normal physiologic state. As regards with thyroid hormone levels, the pregnancy is a state of thyroid hyper-stimulation, leading to increase thyroid hormone levels. The common thyroid diseases during pregnancy are hypothyroidism, hyperthyroidism and postpartum thyroiditis. Our study was to elucidate the role of these hormones during pregnancy in Garhwal region, India.

Materials & Method: The thyroid function tests were carried out by measuring serum levels of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) by ELISA technique in randomly selected 50 pregnant women and 50 non-pregnant healthy women in the age group of 15 - 45 years to find out the alteration in thyroid function tests. Results were calculated by using student's t-test and 0.05 level of significance.

Conclusion: It is found that the mean FT4 and TSH values are significantly decreased (0.05) during pregnancy as compare to the non-pregnant women.


Keywords

Pregnancy, Free Thyroxine (FT4), Free Triiodothyronine (FT3), Thyroid Stimulating Hormone (TSH), Thyroid Function Test
Subscription Login to verify subscription
User
Notifications
Font Size


  • Lazarus JH. Thyroid disorders associated with pregnancy: etiology, diagnosis and management. Treat Endocrinol 2005; 4(1): 31-41.

  • Montoro MN. Management of hypothyroidism during pregnancy. Clin Obstet Gynecol 1997;40:65-80

  • Klein RZ, Haddow JE, Faix JD. Prevalence of thyroid deficiency in pregnant women. Clin EndocrinoI 1991; 35:41-8.

  • Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999;341 :549-55.

  • Klein RZ, Haddow JE, Faix JD. Prevalence of thyroid deficiency in pregnant women. Clin EndocrinoI1991; 35:41-8.

  • Kamijo K, Saito T, Sato M et al. Transient subclinical hypothyroidism in early pregnancy. Endocrinol Jpn 1998; 37:397-403.

  • Roti E, Minelli R, Salvi M. Management of hyperthyroidism and hypothyroidism in pregnant woman. J Clin Endocrinol Metab 1996;81: 1679- 1682

  • Thyroid disease in pregnancy. ACOG Technical Bulletin Number 181—June 1993. [Guideline, Journal Article, Practice Guideline]: Int J Gynaecol Obstet 1993 Oct; 43(1):82-8.

  • Girling JC. Thyroid disease and pregnancy. Br J Hosp Med 1996; 56:316- 320 20.

  • Eeker JL, Muse TJ. Thyroid function and disease in pregnancy. Curr Probobstet Gynecol fertile 2000; 23: 1 09-22.

  • Nelson- Piercy C. Thyroid disease. In:. Handbook of Obstetric Medicine. Oxford: ISIS Medical Media, 1997; 80- 94.

  • Lao TT. Thyroid disorders in pregnancy. Curr Opin Obstet Gynecol 2005 Apr; 17(2):123-7

  • Nosratollah Zarghami, Mohammad Rohbani- Noubar and Ali Khosrowbeygi. Thyroid Hormone status during pregnancy in normal Iranian women; Indian Journal of clinical Biochemistry, 2005, 20 (2) 182-185

  • Panesar, N.S. Li, C.Y. and Rogers M.S. (2001) Reference intervals for thyroid hormone in Pregnant Chinese women. Ann. Clin. Biochemistry.38, 329-332.

  • Mc. Edluff, A (1999) Measurement of Free thyroxine (T4) level in Pregnancy. Aust, N.Z. J. obstet, Gynecol 39 158-161.

  • Eram, C, Kangaci H. Karaham, C,mocan, M.Z.and Teltar M.(2001) Thyroid Function Tests in Pregnant women with and without goiter in the eastern black sea region, Gynecol. Endocrinol. 15, 293-297.

  • Kabyemela E. A. R., Swinkels L. M. J. W. Chuwa L.M.M, Ross H.A., Dolmans W.M.V. and Benraad T. J.: Thyroid Function Studies in Normal Pregnant Tanzanian Women: Am. J. Trop. Med. Hyg., 54(1), 1996, pp. 58-61

  • Melahat Dönmez, Tolga Sisli, Flame Fire, Yavuz Aydin: Spontaneous abortion and Thyroid Functions: Perinatal Journal 2005; 13 (2): 110-113.

  • Aboud Eltom. Thyroid hormones and iodine status in Sudanese pregnant women with goiter: International Journal of Food Sciences and Nutrition, 1999, Vol. 50, No. 2, Pages 105-109, DOI 10.1080/096374899101292

  • Juan C. Galofre and Terry F. Davies: Autoimmune thyroid disease in pregnancy: A review: J Womens Health (Larchmt). 2009 November, 18(11): 1847- 1856


Abstract Views: 388

PDF Views: 0




  • A Study of Thyroid Function Tests in Pregnant and Non - Pregnant Women in the Reproductive Age Group of the Garhwal Region of Uttarakhand - India

Abstract Views: 388  |  PDF Views: 0

Authors

J B Gogoi
Dept of Biochemistry, VCSG Govt Medical Science & Research Institute, Srikot, Srinagar (Pauri), Uttarakhand, India
Amit K Singh
Dept of Community Medicine, VCSG Govt Medical Science & Research Institute, Srikot, Srinagar (Pauri), Uttarakhand, India
Sukesh Mukherjee
Dept of Biochemistry, VCSG Govt Medical Science & Research Institute, Srikot, Srinagar (Pauri), Uttarakhand, India

Abstract


Background: Pregnancy is associated with significant but reversible changes in thyroid function tests which are among the most profound to be seen as a result of a normal physiologic state. As regards with thyroid hormone levels, the pregnancy is a state of thyroid hyper-stimulation, leading to increase thyroid hormone levels. The common thyroid diseases during pregnancy are hypothyroidism, hyperthyroidism and postpartum thyroiditis. Our study was to elucidate the role of these hormones during pregnancy in Garhwal region, India.

Materials & Method: The thyroid function tests were carried out by measuring serum levels of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) by ELISA technique in randomly selected 50 pregnant women and 50 non-pregnant healthy women in the age group of 15 - 45 years to find out the alteration in thyroid function tests. Results were calculated by using student's t-test and 0.05 level of significance.

Conclusion: It is found that the mean FT4 and TSH values are significantly decreased (0.05) during pregnancy as compare to the non-pregnant women.


Keywords


Pregnancy, Free Thyroxine (FT4), Free Triiodothyronine (FT3), Thyroid Stimulating Hormone (TSH), Thyroid Function Test

References