Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Correlation of C-Reactive Protein with Body Mass Index and Blood Pressure in Young Adult North Indian Hypertensive Males-a Prospective Study


Affiliations
1 Department of Physiology, Subharti Medical College, N H-58 Meerut-250005, India
2 Department of Microbiology, Subharti Medical College, Meerut, India
3 Department of Medicine, Subharti Medical College, Meerut, India
4 Department of Physiology, Subharti Medical College, Meerut, India
5 Department of Biostatistics, Subharti Medical College, Meerut, India
     

   Subscribe/Renew Journal


Background & Objectives: High blood pressure has been associated with elevated C-reactive protein (CRP), a possible marker of vascular inflammation. The aim of this study was to assess the interrelationship between blood pressure and CRP in young adult north Indian males.

Method: A total of 30 patients with mild to moderate essential hypertension in the age group of 25- 40 years were enrolled for the study. Patients with history of secondary or malignant hypertension were excluded. Age and sex matched healthy normotensive subjects (n=35) were taken as control. The parameters studied were BMI, Systolic (SBP), diastolic (DBP) blood pressure and CRP. C-reactive protein was measured by RHELAX CRP slide test. Statistical analysis was done by using Karl-Pearson correlation coefficient and Student's unpaired t test.

Results: We have observed significant differences (P0.01) association between blood pressure and CRP levels in the study group.

Conclusion: Further studies are needed to explore the relationship between blood pressure and CRP using highly sensitive assays as a major screening test in the prediction, diagnosis and management of essential hypertension.


Keywords

BMI, Blood Pressure, C-Reactive Protein, Young Indian Adults
Subscription Login to verify subscription
User
Notifications
Font Size


  • Antezana FS. Epidemiologic aspects of hypertension in the world. WHO Tech Rep Ser. 1996; No. 862.

  • Park K. Hypertension.In: Park’s text book of preventive & social medicine 19th ed 2007; 309-314.

  • Das SK, Sanyal K and Basu A. Study of urban community survey in India: Growing trend of high prevalence of hypertension in a developing country. Int J Med Sci 2005; 2:70-78.

  • Intengan HD and Schiffrin EL. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 2001; 38: 581-587.

  • Venugopal SK. Devaraj S, Yuhanna I, et al. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 2002; 106: 1439-1441.

  • Lagrand WK, Visser CA, Hermens WT, et al. Creactive protein as a cardiovascular risk factor: more than an epiphenomenon. circulation 1999; 100: 96-102.

  • Pasceri V, Willerson JT, Yeh ET, et al. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000; 102: 2165-2168.

  • Bautista LE, Lopez-Jaramillo P, Vera LM, et al. Is C-reactive protein an independent risk factor for essential hypertension? J Hypertens 2001; 19: 857- 861.

  • Sung KC, Suh JY, Kim BS, et al. High sensitivity C-reactive protein as an independent risk factor for essential hypertension. American Journal of Hypertension 2003 ; 16: 429-433.

  • Clearfield MB. C-reactive potein :A new risk assessment tool for cardio vascular disease. JAOA 2005, 105: 409-416.

  • Chambers JC, Eda S, Bassett P, et al. C-reactive protein, insulin resistance, central obesity and coronary heart disease risk in Indian Asians from the United Kingdom compared with Europian Whites. Circulation 2001:104:145-150.

  • Chandalia M, Cabo-chan Av Jr, Devraj S, Jialal I,Grundy SM and Abate N. Elevated plasma high sensitivity C-reactive protein concentration in Asian Indians living in the United States. J Clin Endocrinol Metab 2003:88:3773-3776.

  • Gupta M, Singh N and Verma J. South Asians and cardiovascular risk. Circulation 2006; 113: 924-929.

  • Dar MS, Pandith AA, Sameer AS, Sultan M, YousufA and Mudassar S. hs-CRP: a potential marker for hypertension in Kashmiri population. Ind J Clin Biochem 2010;25:208-212.

  • Shalia KK, Mashru MR, Vasvani JB, Mokal RA, Mithbawkar SM and Thakur PK . Circulating levels of cell adhesion molecules in hypertension. Ind J Clin Biochem 2009; 24: 388- 397.

  • Cao JJ, Thach C, Manolio TA, et al. C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: The Cardiovascular Health study. Circulation 2003; 108: 166-170.

  • Tracy RP, Lemaitre RN, Psaty BM, et al. Relationship of C-reactive protein to risk of cardiovascular disease in the elderly: results from the Cardiovascular Health study and the Rural Health Promotion Project. Arterioscler Thromb Vasc Biol 1997;17: 1121-1127.

  • D Napoli M and Papa F. Association between blood pressure and C-reactive protein levels in acute ischemic stroke. Hypertension 2003; 42:1117-1123.

  • Lakoski SG, Herrington DM, Siscovick DM and Hulley SB. C-reactive protein concentration and incident hypertension in young adults. The CARDIA study. Arch Intern Med 2006; 166: 345-349.

  • Abramson JL, Weintraub WS and Vaccarino V. Association between pulse pressure and Creactive protein among apparently healthy US adults. Hypertension 2002; 39:197-202.

  • Gupta R, Misra A ,Vikram NK, et al. Younger age of escalation of cardiovascular risk factors in Asian Indian subjects. BMC Cardiovasc disord 2009;9: 28.

  • Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Prevention Detection, Evaluation & treatment of high blood pressure: The JNC 7 report. JAMA 2003; 289 : 2560-2571.

  • Gabay C and Kushner I. Mechanisms of disease: acute-phase proteins and other systemic responses to inflammation. N Eng J Med 1999; 340 : 448-454.

  • Tillet WS and Francis TJr. Serological reactions in pneumonia with non-protein somatic fraction of pneumococcus. J Exp Med 1930; 52:561-571.

  • Das UN. Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period. J Assoc Physicians India 2006; 54:133-142.

  • Jialal I, verma S and devraj S. Inhibition of endothelial NO synthase by C-reactive protein: clinical relevance. Clin Chem 2009; 55: 206-208.

  • Wang CH, Li SH, Weisel RD, et al. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation 2003; 107: 1783-1790.

  • Verma S, Li SH, Weisel RD, et al. Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein. Circulation 2002; 105: 1890-1896.

  • Kumar KV and Das UN. Are free radicals involved in the pathobiology of human essential hypertension? Free Rad Res Commun 1993; 19: 59-66.

  • SaijoY, Kiyota N , Kawasakin Y,et al. Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects. Diabetes, Obesity and Metabolism 2004 ; 6: 249-258.

  • Mohan V, Deepa R and Velmurugan K. Asssociation of C-reactive protein with body fat, diabetes and coronary artery disease in Asian Indians:The Chennai Urban-Rural Epidemiology Study (CURES -6). Diabetic Medicine 2005 ; 22: 863-870.

  • Vikram NK, Misra A,Dwivedi M, et al. Correlations of C-reactive protein levels with anthropometric profile, percentage of body fat and lipids in healthy adolescents and young adults in urban North India. Atherosclerosis 2003;168 :305-313.

  • Pearson TA, Mcnsah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the centers for Disease Control and Prevention and the American Heart Association. Circulation 2003;107: 499-511.


Abstract Views: 412

PDF Views: 0




  • Correlation of C-Reactive Protein with Body Mass Index and Blood Pressure in Young Adult North Indian Hypertensive Males-a Prospective Study

Abstract Views: 412  |  PDF Views: 0

Authors

Kiran Singh
Department of Physiology, Subharti Medical College, N H-58 Meerut-250005, India
Anita Pandey
Department of Microbiology, Subharti Medical College, Meerut, India
Tanuraj Sirohi
Department of Medicine, Subharti Medical College, Meerut, India
Rajesh Misra
Department of Physiology, Subharti Medical College, Meerut, India
Rupesh Tewari
Department of Biostatistics, Subharti Medical College, Meerut, India

Abstract


Background & Objectives: High blood pressure has been associated with elevated C-reactive protein (CRP), a possible marker of vascular inflammation. The aim of this study was to assess the interrelationship between blood pressure and CRP in young adult north Indian males.

Method: A total of 30 patients with mild to moderate essential hypertension in the age group of 25- 40 years were enrolled for the study. Patients with history of secondary or malignant hypertension were excluded. Age and sex matched healthy normotensive subjects (n=35) were taken as control. The parameters studied were BMI, Systolic (SBP), diastolic (DBP) blood pressure and CRP. C-reactive protein was measured by RHELAX CRP slide test. Statistical analysis was done by using Karl-Pearson correlation coefficient and Student's unpaired t test.

Results: We have observed significant differences (P0.01) association between blood pressure and CRP levels in the study group.

Conclusion: Further studies are needed to explore the relationship between blood pressure and CRP using highly sensitive assays as a major screening test in the prediction, diagnosis and management of essential hypertension.


Keywords


BMI, Blood Pressure, C-Reactive Protein, Young Indian Adults

References