Indian Journal of Public Health Research & Development

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Clinico-Hematological Profile of Pancytopenia in North Karnataka-One Year Study


Affiliations
1 Department of Pathology, JJM Medical College, Davangere-577004, Karnataka, India
2 Department of Pathology, J J M Medical College, Davangere, Karnataka, India
3 Department of Forensic Medicine, J J M Medical College, Davangere, Karnataka, India
     

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Pancytopenia is a common hematological problem in India. This study was carried out to identify the causes of pancytopenia. It was a prospective study conducted at the department of Pathology, KIMS, Hubli, India for a duration of one year.A total of 137 cases, which met the criteria for pancytopenia were included in the study. Complete hemogram, bone marrow examination and other investigations were done in these cases. Megaloblastic anemia, aplastic anemia and malaria are the major causes of pancytopenia in our study. As majority of causes for pancytopenia are treatable, a proper work-up to detect the underlying etiology should be attempted in all cases of pancytopenia.

Keywords

Pancytopenia, Megaloblastic Anemia, Aplastic Anemia
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  • Kumar R, Kalra SP, Kumar H, Anand AC and Madan H. Pancytopenia—a six year study. J Assoc Physicians India. 2001; 49:1078-81.

  • Khunger JM, Arulselvi S, Sharma U, Ranga S and Talib VH. Pancytopenia—A clinicohaematological study of 200 cases. Indian J Pathol Microbiol. 2002; 45:375-9.

  • Tilak V and Jain R. Pancytopenia—a clinicohematologic analysis of 77 cases. Indian J Pathol Microbiol. 1999; 42:399-404.

  • Varma N and Dash S. A reappraisal of underlying pathology in adult patients presenting with pancytopenia. Trop Geogr Med. 1992; 44:322-7.

  • Khodke K, Marwah S, Bux G, Yadav RB and Chaturvedi NK. Bone marrow examination in cases of pancytopenia. J Indian Acad Clin Med. 2001; 2:55-9.

  • Jha A, Sayami G, Adhikari RC, Panta AD and Jha R. Bone marrow examination in cases of pancytopenia. J Nepal Med Assoc. 2008; 47:12-7.

  • Bhatnagar SK, Chandra J, Narayan S, Sharma S, Singh V and Dutta AK. Pancytopenia in children: Etiological profile. J Trop Pediatr. 2005;51:236-9.

  • Keisu M and Ost A. Diagnosis in patients with severe pancytopenia suspected of having aplastic anaemia.Eur J Haematol. 1990; 45: 11-4.

  • Hossain MA, Akond AK and Chowdhary MK. Pancytopenia – A study of 50 cases. Bangladesh Journal of Pathology. 1992; 1: 9-12.

  • Singh KJ, Ahluwalia G, Sharma SK,Saxena R, Chaudhary VP andAnant M.Significance of haematological manifestations in patients with tuberculosis. J Assoc Physicians India.2001;49:788,790-4.

  • Yadav TP, Mishra S and Sachadeva KJ. Pancytopenia in disseminated tuberculosis. Indian Pediatr. 1996; 33:587-9.

  • Basu S, Mohan H and Malhotra H. Pancytopenia due to hemophagocytic syndrome as the presenting manifestation of tuberculosis. J Assoc Physicians India. 2000; 48:845-6.

  • Ma Y,Li Z, Chen G et al. Short term complete remission of a patient with human T lymphotropic virus type I associated adult T- cell leukemia / lymphoma with pacytopenia by sequential high dose methyl prednisolone and cyclosporine. Clin Med J.2001; 114:428-30.

  • International agranulocytosis and aplastic anemia study . Incidence of aplastic anemia, the relevance of diagnostic criteria. Blood 1987; 70:1718-21.

  • Dikshit B, Wanchu A, Sachdeva RK, Sharma A and Das R. Profile of hematological abnormalities of Indian HIV infected individuals.BMC Blood Disorders. 2009 Aug 13; 9:5.

  • Khanduri U and Sharma A. Megaloblastic anaemia: Prevalence and causative factors. Natl Med J India.2007; 20(4):172-5.

  • Santra G and Das BK. A cross-sectional study of the clinical profile and etiological spectrum of pancytopenia in a tertiary care centre. Singapore Med J. 2010; 51(10):806-12.

  • Ashraf S and Naeem S. Frequency of Hypersplenism in Chronic Liver Disease Patients Presenting with Pancytopenia. Special edition Annals.2010; 16(1):108-110.

  • Wen JQ, Feng HL, Wang XQ and Pang JP. Hemogram and bone marrow morphology in children with chronic aplastic anemia and myelodysplastic syndrome.World J Pediatr. 2008; 4(1):36-40.

  • Gayathri BN and Rao KS. Pancytopenia : A Clinico-Hematological study. Journal of laboratory physicians. 2011; 3(1):15-20.

  • Ishtiaq O, Baqai HZ, Anwer F and Hussain N. Patterns of pancytopenia patients in a general medical ward and a proposed diagnostic approach. J Ayub Med Coll Abbottabad. 2004 ; 16(1): 8-13.


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  • Clinico-Hematological Profile of Pancytopenia in North Karnataka-One Year Study

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Authors

Seema Bijjaragi
Department of Pathology, JJM Medical College, Davangere-577004, Karnataka, India
Vardendra G Kulkarni
Department of Pathology, J J M Medical College, Davangere, Karnataka, India
Satish L Belagatti
Department of Pathology, J J M Medical College, Davangere, Karnataka, India
Sunil S Kadam
Department of Forensic Medicine, J J M Medical College, Davangere, Karnataka, India

Abstract


Pancytopenia is a common hematological problem in India. This study was carried out to identify the causes of pancytopenia. It was a prospective study conducted at the department of Pathology, KIMS, Hubli, India for a duration of one year.A total of 137 cases, which met the criteria for pancytopenia were included in the study. Complete hemogram, bone marrow examination and other investigations were done in these cases. Megaloblastic anemia, aplastic anemia and malaria are the major causes of pancytopenia in our study. As majority of causes for pancytopenia are treatable, a proper work-up to detect the underlying etiology should be attempted in all cases of pancytopenia.

Keywords


Pancytopenia, Megaloblastic Anemia, Aplastic Anemia

References