Indian Journal of Public Health Research & Development

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Presence of Candida in Oral Dysplastic Lesions-a Casual Involvement or a Causal Role?


Affiliations
1 Oral & Maxillofacial Pathology department, Government Dental College and Hospital, Ahmedabad, Gujarat, India
2 Department of Dentistry, P. D. U. Medical College and Hospital, Rajkot, India
3 Oral & Maxillofacial Pathology Department, Government Dental College and Hospital, Ahmedabad, Gujarat, India
     

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Previous evidences have suggested a strong association between the presence of Candida albicans and the development of oral epithelial dysplasia/neoplasia. The aim of the present study was to determine the role of C. albicans in the development of oral dysplastic lesions on the basis of quantifying the level of colonization and correlating it with the degree of epithelial dysplasia present. The present study comprised of 50 patients who had different oral dysplastic lesions and showed epithelial dysplasia histopathologically. For the isolation of Candida saliva samples were obtained by oral rinse technique while for the detection of fungal hyphae in the tissue sections biopsy specimens were collected from each patient. Significantly (P=0.002) more number of patients with moderate or severe epithelial dysplasia showed higher level of colonization (over 1000 CFU/ml) than patients with mild epithelial dysplasia. In PAS stained tissue sections hyphae were detected in 33% of the patients with moderate or severe epithelial dysplasia whilst there were no hyphae detected in any of the patients with mild epithelial dysplasia. The difference being statistically highly significant (P=0.001). Thus, the present study reveals a significant correlation between Candida infection and the severity of epithelial dysplasia by showing a statistically significant association between high amount of Candida and moderate or severe epithelial dysplasia.

Keywords

Candida Albicans, Oral Epithelial Dysplasia, Oral Dysplastic Lesions, Potentially Malignant Lesions
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  • Presence of Candida in Oral Dysplastic Lesions-a Casual Involvement or a Causal Role?

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Authors

Sima Odedra
Oral & Maxillofacial Pathology department, Government Dental College and Hospital, Ahmedabad, Gujarat, India
Jyoti Chawda
Oral & Maxillofacial Pathology department, Government Dental College and Hospital, Ahmedabad, Gujarat, India
Rahul Rupapara
Department of Dentistry, P. D. U. Medical College and Hospital, Rajkot, India
Pratik Rupakar
Oral & Maxillofacial Pathology Department, Government Dental College and Hospital, Ahmedabad, Gujarat, India

Abstract


Previous evidences have suggested a strong association between the presence of Candida albicans and the development of oral epithelial dysplasia/neoplasia. The aim of the present study was to determine the role of C. albicans in the development of oral dysplastic lesions on the basis of quantifying the level of colonization and correlating it with the degree of epithelial dysplasia present. The present study comprised of 50 patients who had different oral dysplastic lesions and showed epithelial dysplasia histopathologically. For the isolation of Candida saliva samples were obtained by oral rinse technique while for the detection of fungal hyphae in the tissue sections biopsy specimens were collected from each patient. Significantly (P=0.002) more number of patients with moderate or severe epithelial dysplasia showed higher level of colonization (over 1000 CFU/ml) than patients with mild epithelial dysplasia. In PAS stained tissue sections hyphae were detected in 33% of the patients with moderate or severe epithelial dysplasia whilst there were no hyphae detected in any of the patients with mild epithelial dysplasia. The difference being statistically highly significant (P=0.001). Thus, the present study reveals a significant correlation between Candida infection and the severity of epithelial dysplasia by showing a statistically significant association between high amount of Candida and moderate or severe epithelial dysplasia.

Keywords


Candida Albicans, Oral Epithelial Dysplasia, Oral Dysplastic Lesions, Potentially Malignant Lesions

References