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Giant Cell Tumour of Tendon Sheath: a Clinicopathological Study
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Giant cell tumour of tendon sheath is second most common tumour of hand with high incidence of recurrence. It is slowly progressing benign tumour arising from synovial cells of tendon sheath. It occurs at any age with peak incidence in third to fourth decade. Trauma, inflammation, metabolic diseases and a neoplastic etiology are considered as etiological factors.
Aim of study: This study was conducted to share our experience of Clinicopathological aspects of Giant cell tumours of tendon sheath including their relative frequencies as per age and sex distributions, anatomical Sites of occurrence, Fine needle aspiration cytology findings &, histopathology features in School of Medical Science Greater Noida.
Material & Methods: This is a retrospective study of Giant cell tumour of tendon sheath which was done at School of Medical sciences & Research Gr. Noida U.P India during four years from 2008 t0 2012.P atients were examined clinically, FNAC & Biopsy were done and FNAC and histopathological features were studied .
Results: There were total 5 cases of giant cell tumour of tendon sheath. Most common site was fingers of hand. Age of patients varied from 25 yrs to 60 yrs. Duration of swelling were from 1 year to 3 years. Most of the swelling were approximately 2cms in diameter, firm and painless.
FNAC of the swellings revealed sheets and clusters of oval to spindle cells intermixed with mononuclear cells and osteoclast type of giant cells, suggestive of Giant cell tumour of tendon sheath.
Histopathological findings were characteristic of GCT-TS showing foamy histiocytes, multinucleate giant cells, fibroblast like cells and foamy histiocytes. Hemosiderin laden macrophages were seen in two cases ,one case revealed diffuse fibro histiocytic proliferation
Conclusion: Giant Cell tumour is a relatively rare soft tissue tumour of uncertain histogenesis. Clinical and pathological features identified were same as those of previous studies .The basic aim of management should be early diagnosis with meticulous and complete excision to prevent recurrence.
Keywords
- Glowacki KA, Weiss AP. Giant cell tumours of tendon sheath. Hand clin. 1995; 11:245-53.
- Darwish FM, Haddad WH. Giant cell tumour of tendon sheath: Experience with 52 cases. Singapore Med J. 2008;49(11):879-82.
- Walsh EF, Merchrefe A, Akelman E, Schiller AI. Giant cell tumour of tendon sheath. Am J Orthop (belle Mead NJ). 2005;34(3):116-21.
- Reilly KE, Stern PJ, Dale A. Recurrent giant cell tumour of the tendon sheath. J Hand Surg Am. 1999;24:1298-302.
- Kotwal PP, Gupta V, Malhotra R. Giant cell tumour of tendon sheath-is radiotherapy indicated to prevent recurrence after surgery? J Bone Joint Surg. 2000;82B:571- 573.
- AI-Qattan MM. Giant cell tumour of tendon sheath: classification and recurrence rate. J Hand Surg Br.2001;26(1):72-5.
- Phalen GS, Mc Cormack LG, Gazale WJ. Giant cell tumour of tendon sheath (benign synovioma) in the hand: evaluation of 56 cases. Clin Orthop.1959;15: 140-51.
- David R, Lucas MD. Tenosynovial giant cell tumor. Case report and review. Arch Pathol Lab MED. 2012;136-901-906
- Jaffe HL, LIchtenstien HL, Elsutro CJ. Pigmented villonodularsynovitis, bursitis and tenosynovitis. Arch Pathol 1941; 31:731-65.
- Wright CJE. Benign Giant Cell Synovioma. An investigation of 85 cases. Br J Surg.1951; 38(151):257-71.
- Monaghan H, Salter DM, AI – Naffusi A. Giant cell tumour of tendon sheath (localised nodular tenosynovitis: Clinicopathological features of 71 cases. J ClinPathol. 2001;54 (5):404-7.
- O’ Connell JX, Wehrli BM, Nielsen GP et al. Giant cell tumours of soft tissue: a clinicopathologic study of 18 benign and malignant tumours. Am J Surg Pathol 2000; 24:386-95.
- Rodrigues C, Dasai S, Chinoy R. Giant cell tumour of the tendon sheath: a retrospective study of 28 cases. J SurgOncol 1998; 68:100-3.
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