Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Correlation Study of Duration of Type 2 Diabetes with Severity of Neuropathy


Affiliations
1 Department of Physiology, Bangalore Medical College & Research Institute, Fort, K R road, Bangalore, India
2 Department of Physiology, Bangalore Medical College & Research institute, Bangalore, India
     

   Subscribe/Renew Journal


Background: Duration of diabetes mellitus is an important risk factor for all diabetes-related microvascular complications such as neuropathy, retinopathy, and nephropathy. Up to 7.5% of patients with non-insulin-dependent diabetes mellitus (NIDDM) have clinical neuropathy at the time of diagnosis and this rate increases to 50% among patients who have had diabetes for 25 years.

Objective: The present population study was done to assess the correlation of severity of diabetic neuropathy (mild, moderate, and severe) in type 2 diabetes mellitus with that of the duration of disease

Materials and Method: A population-based sample of 60 persons with type-2 diabetes (identified as per the WHO criteria) underwent Vibration perception threshold (VPT) measurements for diabetic neuropathy grading. Severity of neuropathy was graded into three groups based on VPT score as mild (20-24.99 V), moderate (25-38.99 V), and severe (≥39 V). Chi square test was done to analyze the correlation between duration of the disease and the severity of neuropathy.

Results: There was a positive correlation between the duration of DM & severity of neuropathy, the correlation coefficient was 0.414 and this was statistically significant (p<0.001).

Conclusions: The results suggested highly significant correlation between severity of diabetic neuropathy in type 2 diabetes mellitus with that of the duration of disease, making this group vulnerable for complications such as foot ulceration or lower limb amputation. Preventive strategies and patient education still remain key factors in reducing complication rates and mortality.


Keywords

Type-2 Diabetes Mellitus, Neuropathy
Subscription Login to verify subscription
User
Notifications
Font Size


  • Vinik A, Ullal J, Parson HK, Casellini CM. Diabetic neuropathies: clinical manifestations and current treatment options. Nat Clin Pract Endocrinol Metab. 2006 May;2(5):269-81.

  • Shaw JE, Hodge AM, de Courten M, Dowse GK, Gareeboo H, Tuomilehto J, et al. Diabetic neuropathy in Mauritius: Prevalence and risk factors. Diabetes Res Clin Prac 1998;42:131-9

  • Pirart J. Diabetes mellitus and its degenerative complications: A prospective study of 4,400 patients observed between 1947 and 1973. Diabetes Care 1978;1:168-88.

  • Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a populationbased cohort: The Rochester Diabetic Neuropathy Study. Neurology 1993;43:817-24.

  • Garrow AP, Boulton AJ. Vibration perception threshold--a valuable assessment of neural dysfunction in people with diabetes. Diabetes Metab Res Rev 2006;22:4119.

  • Young MJ, Breddy JL, Veves A, Boulton AJ. The prediction of diabetic neuropathy foot ulceration using vibration perception thresholds. A prospective study. Diabetes Care 1994;17:557-60.

  • Agarwal S, Raman R, Paul PG, Rani PK, Uthra S, Gayathree R, et al. Sankara Nethralaya-Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS 1): Study design and research methodology. Ophthalmic Epidemiol 2005;12:143-53.

  • Shaw JE, Gokal R, Hollis S, Boulton AJ. Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus? Diabetes Res Clin Pract 1998;39:55-61.

  • Vincent AM, Callaghan BC, Smith AL, Feldman EL. Diabetic neuropathy: cellular mechanisms as therapeutic targets. Nat Rev Neurol. 2011;7: 573-583.

  • Veves A, Backonja M, Malik RA. Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options. Pain Med. 2008;9:660-674.

  • Baron R. Peripheral neuropathic pain: from mechanisms to symptoms. Clin J Pain. 2000;16(2 Suppl):S12-S20.

  • Pirart J. [Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (author's transl)]. Diabetes Metab 1977; 3:97.

  • Pirart J. [Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (2nd part) (author's transl)]. Diabetes Metab 1977; 3:173.

  • Pirart J. [Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (3rd and last part) (author's transl)]. Diabetes Metab 1977; 3:245.

  • Young MJ, Boulton AJ, MacLeod AF, et al. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993; 36:150.

  • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352:837.


Abstract Views: 287

PDF Views: 0




  • Correlation Study of Duration of Type 2 Diabetes with Severity of Neuropathy

Abstract Views: 287  |  PDF Views: 0

Authors

M S Kusumadevi
Department of Physiology, Bangalore Medical College & Research Institute, Fort, K R road, Bangalore, India
Shivakumar Veeraiah
Department of Physiology, Bangalore Medical College & Research institute, Bangalore, India

Abstract


Background: Duration of diabetes mellitus is an important risk factor for all diabetes-related microvascular complications such as neuropathy, retinopathy, and nephropathy. Up to 7.5% of patients with non-insulin-dependent diabetes mellitus (NIDDM) have clinical neuropathy at the time of diagnosis and this rate increases to 50% among patients who have had diabetes for 25 years.

Objective: The present population study was done to assess the correlation of severity of diabetic neuropathy (mild, moderate, and severe) in type 2 diabetes mellitus with that of the duration of disease

Materials and Method: A population-based sample of 60 persons with type-2 diabetes (identified as per the WHO criteria) underwent Vibration perception threshold (VPT) measurements for diabetic neuropathy grading. Severity of neuropathy was graded into three groups based on VPT score as mild (20-24.99 V), moderate (25-38.99 V), and severe (≥39 V). Chi square test was done to analyze the correlation between duration of the disease and the severity of neuropathy.

Results: There was a positive correlation between the duration of DM & severity of neuropathy, the correlation coefficient was 0.414 and this was statistically significant (p<0.001).

Conclusions: The results suggested highly significant correlation between severity of diabetic neuropathy in type 2 diabetes mellitus with that of the duration of disease, making this group vulnerable for complications such as foot ulceration or lower limb amputation. Preventive strategies and patient education still remain key factors in reducing complication rates and mortality.


Keywords


Type-2 Diabetes Mellitus, Neuropathy

References