A Comparative Study of Random Urine Protein: Creatinine Ratio with 24 Hour Urine Protein Excretion in Diabetic Nephropathy

Renal involvement in diabetes is one of the long term complications leading to morbidity and premature mortality. Proteinuria is the most widely accepted clinical sign of diabetic nephropathy. The present study was a correlation between 24 hour urine protein excretion and random urine protein: creatinine ratio in diabetic subjects for predicting renal involvement. A total of 69 diabetic subjects were studied. It was observed that protein excretion in 24 hr sample correlated significantly with random urine protein: creatinine ratio in physiological and also in nephrotic range of proteinuria. This may have important clinical applications as single urine specimens, which can be collected easily in outpatient clinics and field studies, could replace the more traditional timed urine collections that have been used to assess the risk of clinical diabetic renal disease.