Indian Journal of Public Health Research & Development

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A Comparative Study of Random Urine Protein: Creatinine Ratio with 24 Hour Urine Protein Excretion in Diabetic Nephropathy


Affiliations
1 Department of Biochemistry, Sree Siddhartha Medical College and Research Center, Tumkur, Karnataka, India
2 Department of Pathology, Sree Siddhartha Medical College and Research Center, Tumkur, Karnataka, India
     

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Renal involvement in diabetes is one of the long term complications leading to morbidity and premature mortality. Proteinuria is the most widely accepted clinical sign of diabetic nephropathy. The present study was a correlation between 24 hour urine protein excretion and random urine protein: creatinine ratio in diabetic subjects for predicting renal involvement. A total of 69 diabetic subjects were studied. It was observed that protein excretion in 24 hr sample correlated significantly with random urine protein: creatinine ratio in physiological and also in nephrotic range of proteinuria. This may have important clinical applications as single urine specimens, which can be collected easily in outpatient clinics and field studies, could replace the more traditional timed urine collections that have been used to assess the risk of clinical diabetic renal disease.

Keywords

Diabetic Nephropathy, Protein:Creatinine Ratio
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  • A Comparative Study of Random Urine Protein: Creatinine Ratio with 24 Hour Urine Protein Excretion in Diabetic Nephropathy

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Authors

Hamsaveena
Department of Biochemistry, Sree Siddhartha Medical College and Research Center, Tumkur, Karnataka, India
M. V. Rashmi
Department of Pathology, Sree Siddhartha Medical College and Research Center, Tumkur, Karnataka, India

Abstract


Renal involvement in diabetes is one of the long term complications leading to morbidity and premature mortality. Proteinuria is the most widely accepted clinical sign of diabetic nephropathy. The present study was a correlation between 24 hour urine protein excretion and random urine protein: creatinine ratio in diabetic subjects for predicting renal involvement. A total of 69 diabetic subjects were studied. It was observed that protein excretion in 24 hr sample correlated significantly with random urine protein: creatinine ratio in physiological and also in nephrotic range of proteinuria. This may have important clinical applications as single urine specimens, which can be collected easily in outpatient clinics and field studies, could replace the more traditional timed urine collections that have been used to assess the risk of clinical diabetic renal disease.

Keywords


Diabetic Nephropathy, Protein:Creatinine Ratio

References