Indian Journal of Public Health Research & Development

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Comparative Study of Lipid Profile in Chronic Smokers with and without Acute Myocardial Infarction


Affiliations
1 Dept. of Biochemistry, D. Y. Patil Medical College, Khollapur, Maharashtra, India
2 Dept. of Community Medicine S.N. Medical College, Bagalkot, Karnataka, India
3 Dept. of Biochemistry, S.N. Medical College, Bagalkot, Karnataka, India
4 Dept. of Biochemistry, SIMS Shimoga , Karnataka, India
5 Dept. of Biochemistry, M.R. Medical College, Gulbarga, Karnataka, India
     

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Background

Smoking is one of the major risk factors in the genesis of coronary atherosclerosis and development of coronary heart disease. Smoking may alter normal plasma lipoprotein levels.

Objective

The present study was undertaken to compare the lipid profile between chronic smokers (Group A) and chronic smokers with myocardial infarction (Group B).

Material and Methods

Fifty apparently healthy chronic smokers and 50 smokers with myocardial infarction were selected for the study. Fasting venous blood sample was collected in controls, in AMI patients sample was collected before any intervention, and total cholesterol (TC), triglycerides (TG), and high density lipoprotein cholesterol (HDL-C) were measured. Low density lipoprotein cholesterol (LDL-C) and Very low density lipoprotein cholesterol (VLDL-C) were calculated by Friedwald's formula. Statistical analysis was done by Z test.

Results

The lipid profile was compared between Group A and Group B. There was a significant rise in TC, TG, LDL-C, VLDL-C and significant decrease in HDL-C in Group B as compared to Group A.

Conclusion

Cigarette smoking modulates the IHD risk through geneenvironment interaction and smoking increases the risk of atherosis. Further studies are required to ascertain the gene environment interaction .


Keywords

Chronic Smokers, Myocardial Infarction, Lipid Profile
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  • Comparative Study of Lipid Profile in Chronic Smokers with and without Acute Myocardial Infarction

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Authors

Pampareddy B. Kollur
Dept. of Biochemistry, D. Y. Patil Medical College, Khollapur, Maharashtra, India
R. Manjula
Dept. of Community Medicine S.N. Medical College, Bagalkot, Karnataka, India
Sangappa V. Kashinakunti
Dept. of Biochemistry, S.N. Medical College, Bagalkot, Karnataka, India
Gurupadappa S. Kallaganada
Dept. of Biochemistry, SIMS Shimoga , Karnataka, India
Jagadish B. Ingin
Dept. of Biochemistry, M.R. Medical College, Gulbarga, Karnataka, India

Abstract


Background

Smoking is one of the major risk factors in the genesis of coronary atherosclerosis and development of coronary heart disease. Smoking may alter normal plasma lipoprotein levels.

Objective

The present study was undertaken to compare the lipid profile between chronic smokers (Group A) and chronic smokers with myocardial infarction (Group B).

Material and Methods

Fifty apparently healthy chronic smokers and 50 smokers with myocardial infarction were selected for the study. Fasting venous blood sample was collected in controls, in AMI patients sample was collected before any intervention, and total cholesterol (TC), triglycerides (TG), and high density lipoprotein cholesterol (HDL-C) were measured. Low density lipoprotein cholesterol (LDL-C) and Very low density lipoprotein cholesterol (VLDL-C) were calculated by Friedwald's formula. Statistical analysis was done by Z test.

Results

The lipid profile was compared between Group A and Group B. There was a significant rise in TC, TG, LDL-C, VLDL-C and significant decrease in HDL-C in Group B as compared to Group A.

Conclusion

Cigarette smoking modulates the IHD risk through geneenvironment interaction and smoking increases the risk of atherosis. Further studies are required to ascertain the gene environment interaction .


Keywords


Chronic Smokers, Myocardial Infarction, Lipid Profile

References