Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Oral Plasmablastic Lymphoma in an HIV Negative Patient - a Case Report


Affiliations
1 Dept. of Medical Oncology, KMIO, India
2 Dept. of Medical Oncology, Kidwai Memorial Institute of Oncology, (KMIO), Bangalore -29, India
     

   Subscribe/Renew Journal


Plasmablastic lymphoma (PBL) is a rare variant of a diffuse B-cell lymphoma that is most commonly found in the oral cavity affecting the mucosa, and so named for its blastoid morphology and immunophenotype. Oral PBL has been treated heterogeneously and well defined treatment guidelines are still lacking. It includes chemotherapy, radiotherapy, combination of both or local excision followed by radiation. Prognosis is usually poor regardless of the site of origin. The clinical course is very aggressive with most of the patients dying in the first year after diagnosis. Here we present a case who was treated with high grade lymphoma protocol, CODOX-M alternating with IVAC followed by radiotherapy&Patient showing a good clinical response.

Keywords

Oral Plasmablastic Lymphoma, HIV-Negative, CODOX-M (Cyclophosphamide O-vinccristine DOX-doxorubicin M-methotrexate), IVAC (I-ifosfamide V-vincristine A-cytosine arabinoside C-cisplatin), LCA(Leucocyte Common Antigen)
Subscription Login to verify subscription
User
Notifications
Font Size


  • Cioc AM, Allen C, Kalmar JR, et al: Oral plasmablastic lymphomas in AIDS patients are associated with human herpesvirus 8.Am J Surg Pathol 28:41, 2004

  • Delecluse HJ, Anagnostopoulos F, Dallenbach M, et al: Plasmablastic lymphomas of the oral cavit: A new entity associated with the human immunodeficiency virus infection. Blood 89: 1413, 1997

  • Lester R: Improved outcome of human immunodeficiency virus-associated plasmablastic lymphoma of the oral cavity in the era of highly active antiretroviral therapy: A report of two cases. Leuk Lymphoma 45:1881, 2004

  • Kumar V, Robbins S, Cotran R: Pathologic Basis of Disease. Ed 7. Philadelphia, PA, Elsevier, 2005

  • Jaffe E, Harris N, Stein H, et al: Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. Lyon, IARC Press, 2001

  • Flaitz CM, Nichols CM, Walling DM, et al: Plasmablastic lymphoma: An HIV-associated entity with primary oral manifestations. Oral Oncology 38:96, 2002.

  • Rafaniello Raviele P, Pruneri G, Maiorano E. Plasmablastic lymphoma. Oral Diseases 2009;15:38–45.

  • Delecluse HJ, Anagnostopoulos I, Dallenbach F, Hummel M, Marafioti T, Schneider U, et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 1997;89:1413–20.

  • Carbone A, Gaidono G, Ferlito A, Rinaldo A, Stein H. AIDSrelated plasmablastic lymphoma of the oral cavity and jaws: a diagnostic dilemma. Ann Otol Rhinol Laryngol 1999;108:95–9.

  • Brown RS, Campbell C, Lishman SC, Spittle MF, Miller RF. Plasmablastic lymphoma: a new subcategory of human immunodeficiency virus-related non- Hodgkin’s lymphoma. Clin Oncol 1998;10:327–9.

  • Vega F, Chang CC, Medeiros LJ, Udden MM, Cho-Vega JH, Lau CC, et al. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol 2005;18:806–15.

  • Scheper MA, Nikitakis NG, Fernandes R, Gocke CD, Ord RA, Sauk JJ. Plasmablastic lymphoma in an HIV-negative patient: a case report and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:198–206.


Abstract Views: 215

PDF Views: 0




  • Oral Plasmablastic Lymphoma in an HIV Negative Patient - a Case Report

Abstract Views: 215  |  PDF Views: 0

Authors

Punit Chitlangia
Dept. of Medical Oncology, KMIO, India
Samit Purohit
Dept. of Medical Oncology, KMIO, India
Chintan Narad
Dept. of Medical Oncology, Kidwai Memorial Institute of Oncology, (KMIO), Bangalore -29, India
Rohan Bhise
Dept. of Medical Oncology, Kidwai Memorial Institute of Oncology, (KMIO), Bangalore -29, India

Abstract


Plasmablastic lymphoma (PBL) is a rare variant of a diffuse B-cell lymphoma that is most commonly found in the oral cavity affecting the mucosa, and so named for its blastoid morphology and immunophenotype. Oral PBL has been treated heterogeneously and well defined treatment guidelines are still lacking. It includes chemotherapy, radiotherapy, combination of both or local excision followed by radiation. Prognosis is usually poor regardless of the site of origin. The clinical course is very aggressive with most of the patients dying in the first year after diagnosis. Here we present a case who was treated with high grade lymphoma protocol, CODOX-M alternating with IVAC followed by radiotherapy&Patient showing a good clinical response.

Keywords


Oral Plasmablastic Lymphoma, HIV-Negative, CODOX-M (Cyclophosphamide O-vinccristine DOX-doxorubicin M-methotrexate), IVAC (I-ifosfamide V-vincristine A-cytosine arabinoside C-cisplatin), LCA(Leucocyte Common Antigen)

References