Indian Journal of Public Health Research & Development

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Gamma Glutamyl Transpeptidase and Total Cholesterol Levels in Smokers and Congestive Cardiac Failure Patients


Affiliations
1 Department of Biochemistry, Navodaya Medical College, Raichur, Karnataka, India
2 Department of Biochemistry, KMC, Manipal University, Mangalore, Karnataka, India
3 Department of Biochemistry, VIMS, Bellary, Karnataka, India
4 Department of Biochemistry, FMMC, Kankanadi, Mangalore, Karnataka, India
5 Department of Anatomy, KSHEMA, Nitte University, Mangalore, Karnataka, India
     

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Background and Objectives

The level of gamma glutamye transpeptidase (GGTP or GGT) is especifically increased in alcoholic liver diseases with biliary obstruction. There are many other diseases where alterations in the level of GGTP are noted. Hence, the study was aimed to estimate the level of GGTP in smokers and congestive cardiac failure (CCF) patients along with total cholesterol (TC).

Material and Methods

35 each clinically diagnosed CCF patients, smokers and normal healthy male subjects were included in the study. GGTP was estimated by enzymatic colorimetric method and total cholesterol by cholesterol oxidase peroxidase method using P-800 chemistry antoanalyser. Statistical analysis was done using ANOVA.

Results

The GGTP and TC levels were significantly (p<0.001) increased in the both CCF patients and smokers but increase is more significant in CCF patients.

Conclusion

GGTP can be used as a potential biomarker along with total cholesterol in cardiovascular diseases especially CCF because of their direct relationship with the indication of atherogenesis.


Keywords

GGTP, TC, CCF, Smokers
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  • Gamma Glutamyl Transpeptidase and Total Cholesterol Levels in Smokers and Congestive Cardiac Failure Patients

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Authors

Sreekantha
Department of Biochemistry, Navodaya Medical College, Raichur, Karnataka, India
Vinodchandran
Department of Biochemistry, KMC, Manipal University, Mangalore, Karnataka, India
M. Amareshwar
Department of Biochemistry, VIMS, Bellary, Karnataka, India
S. S. Avinash
Department of Biochemistry, FMMC, Kankanadi, Mangalore, Karnataka, India
Remya
Department of Anatomy, KSHEMA, Nitte University, Mangalore, Karnataka, India
M. V. Kodliwadmath
Department of Biochemistry, Navodaya Medical College, Raichur, Karnataka, India

Abstract


Background and Objectives

The level of gamma glutamye transpeptidase (GGTP or GGT) is especifically increased in alcoholic liver diseases with biliary obstruction. There are many other diseases where alterations in the level of GGTP are noted. Hence, the study was aimed to estimate the level of GGTP in smokers and congestive cardiac failure (CCF) patients along with total cholesterol (TC).

Material and Methods

35 each clinically diagnosed CCF patients, smokers and normal healthy male subjects were included in the study. GGTP was estimated by enzymatic colorimetric method and total cholesterol by cholesterol oxidase peroxidase method using P-800 chemistry antoanalyser. Statistical analysis was done using ANOVA.

Results

The GGTP and TC levels were significantly (p<0.001) increased in the both CCF patients and smokers but increase is more significant in CCF patients.

Conclusion

GGTP can be used as a potential biomarker along with total cholesterol in cardiovascular diseases especially CCF because of their direct relationship with the indication of atherogenesis.


Keywords


GGTP, TC, CCF, Smokers

References