Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Gamma Glutamyl Transpeptidase and Total Cholesterol Levels in Smokers and Congestive Cardiac Failure Patients


Affiliations
1 Department of Biochemistry, Navodaya Medical College, Raichur, Karnataka, India
2 Department of Biochemistry, KMC, Manipal University, Mangalore, Karnataka, India
3 Department of Biochemistry, VIMS, Bellary, Karnataka, India
4 Department of Biochemistry, FMMC, Kankanadi, Mangalore, Karnataka, India
5 Department of Anatomy, KSHEMA, Nitte University, Mangalore, Karnataka, India
     

   Subscribe/Renew Journal


Background and Objectives

The level of gamma glutamye transpeptidase (GGTP or GGT) is especifically increased in alcoholic liver diseases with biliary obstruction. There are many other diseases where alterations in the level of GGTP are noted. Hence, the study was aimed to estimate the level of GGTP in smokers and congestive cardiac failure (CCF) patients along with total cholesterol (TC).

Material and Methods

35 each clinically diagnosed CCF patients, smokers and normal healthy male subjects were included in the study. GGTP was estimated by enzymatic colorimetric method and total cholesterol by cholesterol oxidase peroxidase method using P-800 chemistry antoanalyser. Statistical analysis was done using ANOVA.

Results

The GGTP and TC levels were significantly (p<0.001) increased in the both CCF patients and smokers but increase is more significant in CCF patients.

Conclusion

GGTP can be used as a potential biomarker along with total cholesterol in cardiovascular diseases especially CCF because of their direct relationship with the indication of atherogenesis.


Keywords

GGTP, TC, CCF, Smokers
Subscription Login to verify subscription
User
Notifications
Font Size


  • Goldberg DM. Structural, Functional and Chemical aspects of GGTP. Crit Rev Clin Lab Sci 1980; 12(1): 1-58.

  • Amadeo J, Pesce and Laurence A. Kaplan methods in Clinical chemistry 1987. C. V. Mos by company Missuri, Chapter 145, 1120-1124.

  • Carl A Burtis and Edward R Ashwood. Tietz Textbook of Clinical chemistry. II edition W.B. Saunders company 1994, Philadelphia. p: 847-851.

  • Kosalki SB, Tarlow D, Raw D Plasma GGTP elevation in patients receiving enzyme including drugs. Lancet 1971; 7720: 376-77.

  • Szasz G, Persijn JP et al. GGTP estimation Zklin chem. Klin Biochem 1974; 12: 228.

  • Tietz NW. Clinical Guide to Laboratory tests, 3rd ed. Philadelphia, Pa:WB Saunders Company ,1995:130-131.

  • Isselbacher, Braumwald, Wilson, Marin, Fauci & Kasper. H.P.I Medicine, Vol II, 13th edition, Mc Graw Hill Publisher 1994: 1446.

  • Schulman JD, Goodman SI, Mace JW et al. Glutathioneria: inborn error of metabolism due to deficiency of GGT. Biochem Biophy Res Commun 1975; 65(1): 68-74.

  • Melissa Palmer M. Hepatitis and Liver disease. Penguin publishers II edition USA 2004: 228.

  • Yokoyama H. Gamma GTP in the era of metabolic syndrome Nihon Arukoru Yakubutsu Igakkai Zasshi 2007, 42(3): 110-124.

  • Pompella A, Emdin M, PassinoC, Paolicchi A. The significance of serum Glutamyl transferase in cardiovascular disease chin chem. Lab Med. 2004; 42: 1085-1091.

  • Betro MG, Oon RC, Edward JB, Gamma- Glutamyl transpeptidase and other LFTs in MI and heart failure. Am J clin pathol. 1973; 60:679-83.

  • Wannamethee G, Ebrahim S, Shaper AG. Gamma- Glutamyl transferase: determinants & association with mortality from is chemic heart disease and all cause. Am J Epidemiol 1995; 142:699- 708.

  • Emdin M, PassinoC, MichelassiC, Titta F, et al prognostic value of serum gamma- Glutamyl transferase activity after MI. Eur Heart J 2001, 22:1802-1807.

  • Jousilahti P, Ranstenyte D, Tuomilehto J. Serum gammaglutamyl transferase, self reported alcohol drinking and the risk of stroke. Stroke 2000; 31: 1851-1855.

  • Paolicchi A, Emdin M, Ghliozeni E, Ciancia E et al Human atherosclerotic Plaque contains gamma-glutamyl transpeptidase activity circulation 2004; 109:1440.

  • Hood B, Kjellstrom T, Ruter G, Kristenson H. Serum cholesterol, triglyceride, alcohol, MI & death: necessary to pay attention to serum GGT in assessment of risk of myocardial.

  • Ainsley Chalmers. Smoking and oxidative stress. Am J Clin Nutr. 1999; 69(3):572.

  • Paolicchi A, Minotti G, Tonarelli P, Tongiani R et al Gammaglutamyl transpeptidase- dependent iron reduction and LDL oxidation: a potential mechanism in atherosclerosis. J Invest Med 1999; 47: 151-160.

  • Hedworth- White RB, Whitfield JB, Richardson RW Serum GGT activity in myocardial ischemia. Br Heart, 1967; 29: 432-438.

  • Emdin M, PassinoC C, Pompella A, Paolicchi A Serum gammaglutamyl transpeptidase: a prognostic marker in cardiovascular diseases. Biofactors 2003; 17: 199-205.

  • Nakanishi N, Suzuki K, Tatara K. Serum-glutamyl transferase and risk of metabolic syndrome and type 2 diabetes in middle aged Japanese men. Diabetes care 2004, 27: 1427-1432.

  • Lee DH, Steffen LM, Jacobs DR. Association between serum glutamyl transferase and dietary factors: the coronary artery risk development in young adults (CARDIA) study. Am J Clin Nutr 2004; 79: 600- 605.


Abstract Views: 300

PDF Views: 0




  • Gamma Glutamyl Transpeptidase and Total Cholesterol Levels in Smokers and Congestive Cardiac Failure Patients

Abstract Views: 300  |  PDF Views: 0

Authors

Sreekantha
Department of Biochemistry, Navodaya Medical College, Raichur, Karnataka, India
Vinodchandran
Department of Biochemistry, KMC, Manipal University, Mangalore, Karnataka, India
M. Amareshwar
Department of Biochemistry, VIMS, Bellary, Karnataka, India
S. S. Avinash
Department of Biochemistry, FMMC, Kankanadi, Mangalore, Karnataka, India
Remya
Department of Anatomy, KSHEMA, Nitte University, Mangalore, Karnataka, India
M. V. Kodliwadmath
Department of Biochemistry, Navodaya Medical College, Raichur, Karnataka, India

Abstract


Background and Objectives

The level of gamma glutamye transpeptidase (GGTP or GGT) is especifically increased in alcoholic liver diseases with biliary obstruction. There are many other diseases where alterations in the level of GGTP are noted. Hence, the study was aimed to estimate the level of GGTP in smokers and congestive cardiac failure (CCF) patients along with total cholesterol (TC).

Material and Methods

35 each clinically diagnosed CCF patients, smokers and normal healthy male subjects were included in the study. GGTP was estimated by enzymatic colorimetric method and total cholesterol by cholesterol oxidase peroxidase method using P-800 chemistry antoanalyser. Statistical analysis was done using ANOVA.

Results

The GGTP and TC levels were significantly (p<0.001) increased in the both CCF patients and smokers but increase is more significant in CCF patients.

Conclusion

GGTP can be used as a potential biomarker along with total cholesterol in cardiovascular diseases especially CCF because of their direct relationship with the indication of atherogenesis.


Keywords


GGTP, TC, CCF, Smokers

References