Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Stem Cell Therapy and Tooth Regeneration - a Review


Affiliations
1 Department of Periodontics, Navodaya Dental College & Hospital, Raichur, India
     

   Subscribe/Renew Journal


Tooth development results from sequential and reciprocal interactions between the oral epithelium and the underlying neural crest derived mesenchyme. The generation of dental structures and / or entire teeth in the laboratory depends upon the manipulation of stem cells and requires a synergy of all cellular and molecular events that finally lead to the formation of tooth specific hard tissues, dentin and enamel. The odontogenic potential resides in the oral epithelium and thus epithelial stem cells are necessary for both the initiation of tooth formation and enamel matrix production. This review focuses on the re-growth of teeth in vitro and their relative efficiency by using stem cells from different sources.

Keywords

Stem Cells, Odontoblast, Dentin, Ameloblasts Enamel, Tooth, Incisor, Human
Subscription Login to verify subscription
User
Notifications
Font Size


  • Amar S.Luo W, Snead ML, Ruch JV (1989). Amelogenin gene expression in mouse incisor heterotopic recombinations. Differentiation 41: 56-61.

  • Bluteau G., Luder, De Basic, Stem cells for tooth engineering, 2008, 1-9.

  • Duailibi MT, Duailibi SE, Young CS, Bartlett JD, Vacanti JP, Yelich PC (2004). Bioengineered teeth from cultured rat tooth bud cells. J. Dent Res 83: 523-528.

  • Duailibi SE, Duailibi MT, Vacanti JP, Yelich PC (2006). prospects for tooth regeneration. Periodontal 2000. 41: 177-187.

  • Gay I, Chen S, Macdong-all M (2007) Isolation and characterization of multipoint human periodontal ligament stem cells. Orthod Craniofac Res 10: 149-160.

  • Gronthos S, Brahim J. Li W, Fisher LW, Cherman N, Shi S (2002) Stem cells properties of human dental pulp Stem cells J Dent Res 81: 531-535.

  • Honda MJ, Tsuchiya S, Sumita Y (2007b) The Sequential seeding of epithelial and mesenchymal cells for tissue engineered tooth regeneration. Biomaterials 28: 680-689.

  • Hu B, Nadiri a, Kuchler - Bopp S. Perrin - Schmitt F, Peters H, Lesot H (2006). Tissue engineering of tooth crown, ischolar_main and periodontium. Tissue Eng 12: 2069-2075.

  • Kawaguchi H, Hirachi A, Hasegawa N, Iwata T, Hamaguchi H, Shiba H, Takata T, Kato Y, Kurihara H (2004) Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells. J Periodontal 75: 1281-1287.

  • Mitsiadis TA, Rahiotis C (2004) Parallels between tooth development and repair: conserved molecular mechanisms following carious and dental injury. J Dent Res 83: 896-902.

  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey P. G., Shi S (2003) SHED: Stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 100: 5807-5812.

  • Nakao K, Morita R, Saji Y, Ishida K, Tomita Y, Ogawa M, Saitoh M, Tomooka Y, Tsuji T (2007).The development of a bioengineered organ germ method. Nat Methods. 4; 227-230.

  • Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276: 71-74.

  • Robey PG (2005) Post-natal stem cells for dental and craniofacial repair. Oral Biosci Med 2: 83-90.

  • Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R, Shi S (2005) Recovery of stem cells from ryopreserved periodontal ligament. J Dent Res 84: 907-912.

  • Sire JY, Davit-Beal T, Delgado S, Gu X (2007) The origin and evolution of enamel mineralization genes. Cells Tissues Organs 186: 25-48.

  • Thesleff I, Wang XP, Suomalainen M (2007) Regulation of epithelial stem cells in tooth regeneration. C R Biol 330: 561-564.

  • Yokoi T, Saito M, Kiyono T, Iseki S, Kosaka K, Nishida E, Tsubakimoto T, Harada H, Eto K, Noguchi T, Teranaka T (2007) Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo. Cell Tissue Res 327: 301-311.

  • Yu J, Wang Y, Deng Z, Tang L, Li Y, Shi J, Jin Y (2007) Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells. Biol Cell 99: 465-474.


Abstract Views: 325

PDF Views: 0




  • Stem Cell Therapy and Tooth Regeneration - a Review

Abstract Views: 325  |  PDF Views: 0

Authors

Surangama Debnath
Department of Periodontics, Navodaya Dental College & Hospital, Raichur, India
G. P. Prafulla
Department of Periodontics, Navodaya Dental College & Hospital, Raichur, India
Anupama Anupama
Department of Periodontics, Navodaya Dental College & Hospital, Raichur, India

Abstract


Tooth development results from sequential and reciprocal interactions between the oral epithelium and the underlying neural crest derived mesenchyme. The generation of dental structures and / or entire teeth in the laboratory depends upon the manipulation of stem cells and requires a synergy of all cellular and molecular events that finally lead to the formation of tooth specific hard tissues, dentin and enamel. The odontogenic potential resides in the oral epithelium and thus epithelial stem cells are necessary for both the initiation of tooth formation and enamel matrix production. This review focuses on the re-growth of teeth in vitro and their relative efficiency by using stem cells from different sources.

Keywords


Stem Cells, Odontoblast, Dentin, Ameloblasts Enamel, Tooth, Incisor, Human

References